Nuclear localization of dirhodium(ii) complexes in breast cancer cells by X-ray fluorescence microscopy.
作者信息
Enriquez Garcia Alejandra, Lai Barry, Gopinathan Sesha Gopal, Harris Hugh H, Shemanko Carrie S, Jalilehvand Farideh
机构信息
Department of Chemistry, University of Calgary, Calgary, AB T2N 1N4, Canada.
Advanced Photon Source, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA.
出版信息
Chem Commun (Camb). 2019 Jul 11;55(57):8223-8226. doi: 10.1039/c9cc00521h.
PMID:31215918
Abstract
The cellular distribution of three dirhodium(ii) complexes with a paddlewheel structure was investigated using synchrotron-based X-ray fluorescence microscopy and cell viability studies. Complexes with vacant axial sites displayed cytotoxic activity and nuclear accumulation whereas complexes in which the axial positions were blocked showed little to no toxicity nor uptake.
摘要
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