白细胞介素 1B 基因与中国维吾尔族人群宫颈癌易感性的相关性：一项病例对照研究。
Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur Population: A Case-Control study.
机构信息
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, People's Republic of China.
School of Basic Medical Sciences, Xizang Minzu University, Xianyang, Shaanxi, People's Republic of China.
出版信息
Mol Genet Genomic Med. 2019 Aug;7(8):e779. doi: 10.1002/mgg3.779. Epub 2019 Jun 20.
BACKGROUND
Interleukin-1β (IL-1B) has been recognized as a pro-inflammatory cytokine and associated with tumorigenesis. We aimed to evaluate the contribution of IL-1B polymorphisms to the susceptibility of cervical cancer in Chinese Uygur population.
METHODS
Seven variants were genotyped by Agena MassARRAY platform in 267 cervical cancer patients and 302 healthy controls. Allelic, genotypic, and haplotypic association analyses adjusted for age were investigated using odds ratios (OR) and 95% confidence intervals (CI). GEPIA and UALCAN databases were used to evaluate expression and prognostic of IL-1B gene in cervical cancer.
RESULTS
Our result revealed IL-1B rs1143627-AA (OR = 1.98, p = 0.029) and rs16944-GG (OR = 2.01, p = 0.025) was associated with an increased risk of cervical cancer. Besides, we also found two protective single nucleotide polymorphisms (SNPs) rs3136558 (OR = 0.63, p = 0.011) and rs1143630 (OR = 0.63, p = 0.019). Haplotype ″TGA″ in the block (rs1143630, rs1143627, and rs16944) significantly decreased the susceptibility of cervical cancer (OR = 0.53, p = 0.0007). IL-1B mRNA level was up-regulated in the cervical cancer patients, which was related with poor prognosis in silico.
CONCLUSIONS
For the first time, our results provide evidence on polymorphism of IL-1B gene associated with cervical cancer risk in Chinese Uygur population.
背景
白细胞介素-1β（IL-1β）已被认为是一种促炎细胞因子，与肿瘤发生有关。我们旨在评估 IL-1B 多态性对中国维吾尔族人群宫颈癌易感性的贡献。
方法
使用 Agena MassARRAY 平台对 267 例宫颈癌患者和 302 例健康对照者的 7 种变体进行基因分型。使用优势比（OR）和 95%置信区间（CI）调整年龄的等位基因、基因型和单倍型关联分析。GEPIA 和 UALCAN 数据库用于评估 IL-1B 基因在宫颈癌中的表达和预后。
结果
我们的结果表明，IL-1B rs1143627-AA（OR=1.98，p=0.029）和 rs16944-GG（OR=2.01，p=0.025）与宫颈癌风险增加相关。此外，我们还发现了两个保护性单核苷酸多态性（SNP）rs3136558（OR=0.63，p=0.011）和 rs1143630（OR=0.63，p=0.019）。该块中的单倍型“TGA”（rs1143630、rs1143627 和 rs16944）显著降低了宫颈癌的易感性（OR=0.53，p=0.0007）。IL-1B mRNA 水平在宫颈癌患者中上调，这与计算机模拟的不良预后相关。
结论
我们的研究结果首次提供了证据，表明 IL-1B 基因多态性与中国维吾尔族人群宫颈癌风险相关。
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