Qan'ir Yousef, DeDeaux Darrell, Godley Paul A, Mayer Deborah K, Song Lixin
University of North Carolina.
Campbell University Health Center.
Oncol Nurs Forum. 2019 Jul 1;46(4):E107-E118. doi: 10.1188/19.ONF.E107-E118.
To determine best practices for managing hot flashes associated with androgen deprivation therapy (ADT) in men with prostate cancer.
The CINAHL®, Embase®, PsycINFO®, PubMed®, and Scopus® databases were used to identify randomized controlled trials (RCTs) and quasiexperimental studies published between January 1994 and June 2018.
Using the Cochrane Handbook for Systematic Reviews of Interventions, the authors reviewed 15 studies examining the effects of pharmacologic or complementary and alternative medicine interventions on ADT-associated hot flashes in men with prostate cancer.
Pharmacologic interventions (e.g., cyproterone, medroxyprogesterone, megestrol acetate) showed some promise for reducing hot flashes but were associated with side effects and risks. Acupuncture demonstrated potential benefit in reducing hot flashes without side effects.
Evidence is insufficient to support interventions for ADT-associated hot flashes in men with prostate cancer. Future RCTs should be sufficiently powered, include a control group, and use standardized outcome measures.
确定前列腺癌男性患者中管理与雄激素剥夺治疗（ADT）相关潮热的最佳实践方法。
使用CINAHL®、Embase®、PsycINFO®、PubMed®和Scopus®数据库来识别1994年1月至2018年6月期间发表的随机对照试验（RCT）和半实验性研究。
作者使用《Cochrane系统评价干预措施手册》，回顾了15项研究，这些研究考察了药物或补充与替代医学干预措施对前列腺癌男性患者ADT相关潮热的影响。
药物干预措施（如环丙孕酮、甲羟孕酮、醋酸甲地孕酮）在减少潮热方面显示出一些前景，但与副作用和风险相关。针灸在减少潮热方面显示出潜在益处且无副作用。
证据不足以支持对前列腺癌男性患者ADT相关潮热的干预措施。未来的随机对照试验应有足够的效力，包括一个对照组，并使用标准化的结局指标。
