[老年转甲状腺素蛋白淀粉样变性伴心脏损害的诊断与治疗问题：临床经验。]

[Problems of diagnostics and treatment of transtiretinum amyloidosis with destruction of the heart in the elderly: Clinical experience.].

作者信息

Boldueva S A, Petrova V B, Khavinson V K, Samohvalova M V, Petrova A I

机构信息

I.I.Mechnikov North-Western State Medical University, 41 Kirochnaya str., St. Petersburg 191015, Russian Federation; e-mail:

出版信息

Adv Gerontol. 2019;32(1-2):137-144.

PMID:31228380

Abstract

The article presents a modern understanding of the treatment of cardiac amyloidosis, provides data on the frequency of occurrence, classification and variants of clinical manifestations of transthyretin amyloidosis. This pathology is a slowly progressive disease, the symptoms of which usually appear in the elderly and senile age. This diagnosis may become more common in the future as the population ages and diagnostic methods improve. As an illustration, a description of the clinical case of transtritin amyloidosis of the heart in a 77-year-old patient, which occurred with a primary lesion of the heart and symptoms of chronic heart failure, is given. It shows the difficulties in the lifetime diagnosis of transthyretin amyloidosis.

摘要

本文介绍了对心脏淀粉样变性治疗的现代认识，提供了关于转甲状腺素蛋白淀粉样变性的发病率、分类及临床表现变体的数据。这种病理是一种缓慢进展的疾病，其症状通常出现在老年人和高龄人群中。随着人口老龄化和诊断方法的改进，这种诊断在未来可能会变得更加普遍。作为例证，给出了一名77岁患者心脏转甲状腺素蛋白淀粉样变性的临床病例描述，该病例以心脏原发性病变和慢性心力衰竭症状出现。它显示了转甲状腺素蛋白淀粉样变性终生诊断中的困难。