Health Research Institute, University of Limerick, V94 T9PX Limerick, Ireland.
Nutrients. 2019 Jun 23;11(6):1413. doi: 10.3390/nu11061413.
The diurnal rhythm of bone remodeling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of bedtime ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or maltodextrin (CON) on acute (0-4 h) blood and 24-h urinary change in biomarkers of bone remodeling in postmenopausal women with osteopenia. In CON, participants received 804 ± 52 mg calcium, 8.2 ± 3.2 µg vitamin D and 1.3 ± 0.2 g/kg BM protein per day. MBPM increased calcium intake to 1679 ± 196 mg, vitamin D to 9.2 ± 3.1 µg and protein to 1.6 ± 0.2 g/kg BM. Serum C-terminal cross-linked telopeptide of type I collagen (CTX) and procollagen type 1 amino-terminal propeptide (P1NP), and urinary N-telopeptide cross-links of type I collagen (NTX), pyridinoline (PYD) and deoxypyridinoline (DPD) was measured. Analyzed by AUC and compared to CON, a -32% lower CTX ( = 0.011, d = 0.83) and 24% ( = 0.52, d = 0.2) increase in P1NP was observed for MBPM. Mean total 24 h NTX excreted in MBPM was -10% ( = 0.035) lower than CON. Urinary PYD and DPD were unaffected by treatment. This study demonstrates the acute effects of bedtime ingestion of a calcium-fortified, milk-based protein matrix on bone remodeling.
骨重建的昼夜节律表明夜间饮食干预最有效。本研究调查了在患有骨质疏松症的绝经后妇女中，睡前摄入强化钙、牛奶来源的蛋白质基质 (MBPM) 或麦芽糊精 (CON) 对急性（0-4 小时）血液和 24 小时尿液中骨重建生物标志物的影响。在 CON 中，参与者每天摄入 804 ± 52 毫克钙、8.2 ± 3.2 微克维生素 D 和 1.3 ± 0.2 克/千克 BM 蛋白质。MBPM 将钙摄入量增加到 1679 ± 196 毫克，维生素 D 增加到 9.2 ± 3.1 微克，蛋白质增加到 1.6 ± 0.2 克/千克 BM。测量血清 I 型胶原 C 端交联肽 (CTX) 和前胶原 I 型氨基端前肽 (P1NP)，以及尿 I 型胶原 N 端肽交联 (NTX)、吡啶啉 (PYD) 和脱氧吡啶啉 (DPD)。通过 AUC 分析并与 CON 进行比较，MBPM 观察到 CTX 降低 32%（ = 0.011，d = 0.83）和 P1NP 增加 24%（ = 0.52，d = 0.2）。MBPM 中总 24 小时 NTX 排泄量平均降低 10%（ = 0.035）低于 CON。尿 PYD 和 DPD 不受治疗影响。本研究表明，睡前摄入强化钙、牛奶来源的蛋白质基质对骨重建具有急性影响。
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