Sangouni Abbas Ali, Ghavamzadeh Saeid, Jamalzehi Atena
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran; Department of Human Nutrition, Medicine Faculty, Urmia University of Medical Sciences, Urmia, Iran.
Department of Human Nutrition, Medicine Faculty, Urmia University of Medical Sciences, Urmia, Iran; Food and Beverage Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Diabetes Metab Syndr. 2019 May-Jun;13(3):2260-2265. doi: 10.1016/j.dsx.2019.05.013. Epub 2019 May 22.
The global prevalence of Non-alcoholic fatty liver disease (NAFLD) is increasing rapidly. Many studies have been conducted on the treatment of NAFLD; nevertheless, there is still no approved drug treatment for this disease. Although the pathogenesis of NAFLD is not fully understood, but inflammation, insulin resistance, oxidative stress, obesity and dyslipidemia are among the main causes. Epidemiological studies have shown that hypovitaminosis D is associated with these factors causing NAFLD. In addition, rate of Vitamin D deficiency has been shown to be directly related to the severity of NAFLD. Accordingly, it is believed that vitamin D may help to treatment of NAFLD by improving the above-mentioned risk factors. The purpose of this review is to survey the recent advances in the field of Vitamin D efficacy on risk factors and the severity of NAFLD based on existing evidence, especially the clinical efficiency of vitamin D supplementation in patients with NAFLD.
非酒精性脂肪性肝病（NAFLD）的全球患病率正在迅速上升。针对NAFLD的治疗已经开展了许多研究；然而，对于这种疾病仍然没有获批的药物治疗方法。尽管NAFLD的发病机制尚未完全明确，但炎症、胰岛素抵抗、氧化应激、肥胖和血脂异常是主要病因。流行病学研究表明，维生素D缺乏与导致NAFLD的这些因素相关。此外，维生素D缺乏率已被证明与NAFLD的严重程度直接相关。因此，人们认为维生素D可能通过改善上述风险因素来帮助治疗NAFLD。本综述的目的是基于现有证据，尤其是维生素D补充剂对NAFLD患者的临床疗效，探讨维生素D在NAFLD风险因素及严重程度方面疗效的最新进展。
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