EB 病毒阳性 T 细胞/自然杀伤细胞淋巴组织增生性疾病患者不同血液成分中的病毒 DNA 载量。

Viral DNA Loads in Various Blood Components of Patients With Epstein-Barr Virus-Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases.

机构信息

Department of Pediatrics, Nagoya University Graduate School of Medicine, Tokyo, Japan.

Department of Virology, Nagoya University Graduate School of Medicine, Tokyo, Japan.

出版信息

J Infect Dis. 2019 Sep 13;220(8):1307-1311. doi: 10.1093/infdis/jiz315.

DOI:10.1093/infdis/jiz315

PMID:31240305

Abstract

To evaluate diagnostic values for Epstein-Barr virus (EBV) DNA loads in different blood components of patients with EBV-positive T-cell/natural killer cell lymphoproliferative diseases, EBV DNA loads were compared among disease categories in each blood component from 59 patients. Plasma viral loads were significantly higher in "active" disease in chronic active EBV infection. EBV DNA was not detected in the plasma from 7 patients in whom EBV DNA was detected in peripheral blood mononuclear cells and whole blood. Diagnostic cutoff values for whole blood EBV DNA loads of patients with chronic active EBV infection compared with those of infectious mononucleosis was 104.2 (15 800) IU/mL.

摘要

为了评估 EBV 阳性 T 细胞/自然杀伤细胞淋巴组织增生性疾病患者不同血液成分中的 EBV DNA 载量的诊断价值，比较了 59 例患者中每种血液成分中不同疾病类别的 EBV DNA 载量。在慢性活动性 EBV 感染的“活动性”疾病中，血浆病毒载量明显更高。7 例患者的血浆中未检测到 EBV DNA，而外周血单个核细胞和全血中检测到 EBV DNA。与传染性单核细胞增多症相比，慢性活动性 EBV 感染患者全血 EBV DNA 载量的诊断截止值为 104.2（15800）IU/mL。