Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
Department of Neurological Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
J Matern Fetal Neonatal Med. 2021 May;34(9):1375-1381. doi: 10.1080/14767058.2019.1637411. Epub 2019 Jul 4.
To evaluate risk for postpartum readmissions and associated severe morbidity by maternal age.
This retrospective cohort study used the Nationwide Readmissions Database to analyze 60-day all-cause postpartum readmission risk from 2010 to 2014. Risk for severe maternal morbidity (SMM) during readmission was ascertained using criteria from the Centers for Disease Control and Prevention. The primary exposure of interest was maternal age. Outcomes included time to readmission, risk of readmission, and risk for SMM during readmission. Multivariable log linear analyses adjusting for patient, obstetric, and hospital factors were conducted to assess readmission and SMM risk with adjusted risk ratios (aRRs) with 95% confidence intervals (CIs) as measures of effect.
Between 2010 and 2014, we identified 15.7 million deliveries, 15% of which were to women aged 35 or older. The 60-day all-cause readmission rate was 1.7%. Of these, 13% were complicated by SMM. Age-stratification revealed that women 35 and older were at increased risk for readmission and increased risk for SMM. The majority of readmissions occurred within the first 20 days regardless of age; although, women 35 and older were more likely to be admitted within the first 10 days of discharge. Patients ages 35-39, 40-44, and >44 years had 9% (95% CI 7-10%), 37% (95% CI 34-39%), and 66% (95% CI 55-79%) significantly higher rates of postpartum readmission when compared to women age 25-29. Women 35-39, 40-44, and >44 years of age had a 15% (95% CI 10-21%), 26% (95% CI 18-34%), and 56% (95% CI 25-94%) higher risk of a readmission with SMM than women 25-29.
AMA women are at higher risk for both postpartum readmission and severe morbidity during readmission. Women older than 35 years represent the group most likely to experience complications requiring readmission, with the highest risk age 40 and older.
评估产妇年龄与产后再入院及相关严重并发症的关系。
本回顾性队列研究利用全国再入院数据库,分析了 2010 年至 2014 年期间 60 天内所有原因的产后再入院风险。使用疾病控制与预防中心的标准确定再入院期间严重产妇并发症(SMM)的风险。主要暴露因素为产妇年龄。研究结局包括再入院时间、再入院风险以及再入院期间发生 SMM 的风险。采用多变量对数线性分析,对患者、产科和医院因素进行调整,以评估再入院和 SMM 风险,并使用调整后的风险比(aRR)和 95%置信区间(CI)作为效应的度量指标。
在 2010 年至 2014 年期间,我们确定了 1570 万例分娩,其中 15%为 35 岁或以上的产妇。60 天内全因再入院率为 1.7%。其中,13%的再入院病例并发 SMM。年龄分层显示,35 岁及以上的产妇再入院风险增加,且 SMM 风险增加。大多数再入院发生在最初的 20 天内,与年龄无关;然而,35 岁及以上的产妇更有可能在出院后的前 10 天内再次入院。与 25-29 岁年龄组相比,35-39 岁、40-44 岁和>44 岁的产妇产后再入院率分别高 9%(95%CI 7-10%)、37%(95%CI 34-39%)和 66%(95%CI 55-79%);35-39 岁、40-44 岁和>44 岁的产妇发生再入院伴 SMM 的风险分别高 15%(95%CI 10-21%)、26%(95%CI 18-34%)和 56%(95%CI 25-94%)。
高龄产妇(AMA)不仅产后再入院风险增加,而且再入院期间严重并发症的风险也增加。35 岁以上的产妇最有可能经历需要再次入院的并发症,其中 40 岁及以上年龄组的风险最高。