Sun Ying-Jian, Zhang Zi-Yuan, Fan Bin, Li Guang-Yu
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, China.
Front Neurosci. 2019 Jun 11;13:586. doi: 10.3389/fnins.2019.00586. eCollection 2019.
Hypothermia therapy is an old and important method of neuroprotection. Until now, many neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation, subarachnoid hemorrhage, spinal cord injury, hepatic encephalopathy, and neonatal peripartum encephalopathy have proven to be suppressed by therapeutic hypothermia. Beneficial effects of therapeutic hypothermia have also been discovered, and progress has been made toward improving the benefits of therapeutic hypothermia further through combination with other neuroprotective treatments and by probing the mechanism of hypothermia neuroprotection. In this review, we compare different hypothermia induction methods and provide a summarized account of the synergistic effect of hypothermia therapy with other neuroprotective treatments, along with an overview of hypothermia neuroprotection mechanisms and cold/hypothermia-induced proteins.
低温疗法是一种古老且重要的神经保护方法。到目前为止，许多神经系统疾病，如中风、创伤性脑损伤、颅内压升高、蛛网膜下腔出血、脊髓损伤、肝性脑病和新生儿围产期脑病，已被证实可通过治疗性低温得到抑制。治疗性低温的有益效果也已被发现，并且在通过与其他神经保护治疗相结合以及探究低温神经保护机制来进一步提高治疗性低温的益处方面已经取得了进展。在这篇综述中，我们比较了不同的低温诱导方法，并总结了低温疗法与其他神经保护治疗的协同作用，同时概述了低温神经保护机制以及冷/低温诱导蛋白。
