Department of Biostatistics, University of Liverpool, Liverpool, UK.
INSERM, U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (CRESS), Methods of Therapeutic Evaluation of Chronic Diseases Team (METHODS), F-75014, Paris, France.
BMC Med. 2019 Jun 28;17(1):121. doi: 10.1186/s12916-019-1361-2.
Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality worldwide. Early interventions may help to delay or prevent onset of cardiometabolic endpoints of clinical importance to T2DM patients.Wijesuriya et al. (BMC Med 15:146, 2017) published results of a randomised controlled trial in Sri Lanka testing the effect of two lifestyle modification programmes of varying intensity in participants aged 5-40 years with risk factors for T2DM. The intervention measured the impact of the two programmes on the primary composite endpoint consisting of various predictors of cardiometabolic disease. The authors concluded that the more intensive programme significantly reduced the incidence of predictors of cardiometabolic disease. Further, they delivered a large-scale intervention with restricted resources with widespread acceptance as demonstrated by the high uptake rate. However, we believe that further analysis is required to fully understand the potential for benefit, particularly in relation to age, retention and missing data.
2 型糖尿病（T2DM）是全球发病率和死亡率的主要原因。早期干预可能有助于延缓或预防 T2DM 患者发生具有临床重要意义的心血管代谢终点事件。Wijesuriya 等人（BMC Med 15:146, 2017）在斯里兰卡发表了一项随机对照试验的结果，该试验测试了两种不同强度的生活方式改变方案对有 T2DM 风险因素的 5-40 岁参与者的影响。该干预措施衡量了这两个方案对主要复合终点的影响，该终点由心血管代谢疾病的各种预测因素组成。作者得出结论，更强化的方案显著降低了心血管代谢疾病预测因素的发生率。此外，他们在资源有限的情况下进行了大规模干预，并得到了广泛认可，因为高参与率证明了这一点。然而，我们认为需要进一步分析以充分了解潜在的益处，特别是与年龄、保留率和缺失数据有关。
