van der Pol Liselotte M, Tromeur Cecile, Faber Laura M, van der Hulle Tom, Kroft Lucia J M, Mairuhu Albert T A, de Roos Albert, Huisman Menno V, Klok Frederikus A
Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Department of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands.
TH Open. 2019 Jan 8;3(1):e22-e27. doi: 10.1055/s-0038-1676812. eCollection 2019 Jan.
The YEARS algorithm was designed to simplify the diagnostic process of suspected pulmonary embolism (PE) and to reduce the number of required computed tomography pulmonary angiography (CTPA) scans. Chest X-ray (CXR) is often used as initial imaging test in patients suspected for PE. To determine if CXR results differ between patients with confirmed PE and with PE ruled out, and to investigate whether CXR provides incremental diagnostic value to the YEARS criteria that is used for selecting patients with CTPA indication. This post-hoc analysis concerned 1,473 consecutive patients with suspected PE who were managed according to YEARS and were subjected to CXR as part of routine care. The prevalence and likelihood ratios of seven main CXR findings for a final diagnosis of PE were calculated. A total of 214 patients were diagnosed with PE at baseline (15%). Abnormal CXR occurred more often in patients with confirmed PE (36%, 77/214) than in patients without PE (26%; 327/1,259), for an odds ratio of 1.60 (95% confidence interval: 1.18-2.18). Only the unexpected finding of a (rib)fracture or pneumothorax, present in as few as six patients (0.4%), significantly lowered the post-test probability of PE to an extent that CTPA could have been avoided. The incremental diagnostic value of CXR to the YEARS algorithm to rule out PE was limited. CXR was more frequently abnormal in patients with PE than in those in whom PE was ruled out. These data do not support to perform CXR routinely in all patients with suspected PE, prior to CTPA imaging.
“ YEARS算法”旨在简化疑似肺栓塞(PE)的诊断过程,并减少所需的计算机断层扫描肺动脉造影(CTPA)扫描次数。胸部X光(CXR)常被用作疑似PE患者的初始影像学检查。
为了确定确诊PE患者和排除PE患者的CXR结果是否存在差异,并研究CXR是否为用于选择CTPA检查适应症患者的YEARS标准提供增量诊断价值。
这项事后分析涉及1473例连续的疑似PE患者,这些患者按照YEARS算法进行管理,并接受CXR作为常规护理的一部分。计算了最终诊断为PE的七种主要CXR表现的患病率和似然比。
共有214例患者在基线时被诊断为PE(15%)。确诊PE的患者中CXR异常的发生率(36%,77/214)高于无PE患者(26%;327/1259),优势比为1.60(95%置信区间:1.18-2.18)。只有(肋骨)骨折或气胸这一意外发现,仅在6例患者(0.4%)中出现,显著降低了PE的检验后概率,以至于可以避免进行CTPA检查。
CXR对YEARS算法排除PE的增量诊断价值有限。PE患者中CXR异常的频率高于排除PE的患者。这些数据不支持在所有疑似PE患者进行CTPA成像之前常规进行CXR检查。