Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Department of Pediatrics, Carmel Medical Center, Haifa, Israel.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Am J Infect Control. 2019 Nov;47(11):1336-1339. doi: 10.1016/j.ajic.2019.04.173. Epub 2019 Jun 26.
Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known nosocomial pathogen in neonatal intensive care unit (NICU) patients. Studies on the impact of MRSA colonization on neonatal morbidities are scarce.
We conducted a 1:3 matched cohort study among infants with and without MRSA colonization, born between January 2010 and June 2014, in a tertiary NICU to review their demographic characteristics and outcomes.
During the study period, rates of MRSA colonization and bacteremia were found to be 0.68% and 0.10%, respectively. No differences in demographic characteristics, mortality, and major morbidities were identified among infants with and without MRSA colonization.
We reported a low rate of MRSA colonization in infants admitted to our NICU, without impact on mortality and inhospital morbidity. Further large-scale studies are needed to understand the implications and cost-effectiveness of active MRSA surveillance.
耐甲氧西林金黄色葡萄球菌（MRSA）是新生儿重症监护病房（NICU）患者中一种众所周知的医院病原体。关于 MRSA 定植对新生儿发病率影响的研究很少。
我们对 2010 年 1 月至 2014 年 6 月期间在一家三级 NICU 出生的 MRSA 定植和非定植婴儿进行了 1:3 匹配队列研究，以回顾他们的人口统计学特征和结局。
在研究期间，MRSA 定植和菌血症的发生率分别为 0.68%和 0.10%。MRSA 定植和非定植婴儿在人口统计学特征、死亡率和主要发病率方面无差异。
我们报告了在我们的 NICU 中住院的婴儿中 MRSA 定植率较低，这对死亡率和住院发病率没有影响。需要进一步开展大规模研究，以了解主动 MRSA 监测的意义和成本效益。
