耐甲氧西林金黄色葡萄球菌定植在三级新生儿重症监护病房婴儿中的流行情况及其临床影响。
Prevalence and clinical impact of methicillin-resistant Staphylococcus aureus colonization among infants at a level III neonatal intensive care unit.
机构信息
Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Department of Pediatrics, Carmel Medical Center, Haifa, Israel.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
出版信息
Am J Infect Control. 2019 Nov;47(11):1336-1339. doi: 10.1016/j.ajic.2019.04.173. Epub 2019 Jun 26.
BACKGROUND
Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known nosocomial pathogen in neonatal intensive care unit (NICU) patients. Studies on the impact of MRSA colonization on neonatal morbidities are scarce.
METHODS
We conducted a 1:3 matched cohort study among infants with and without MRSA colonization, born between January 2010 and June 2014, in a tertiary NICU to review their demographic characteristics and outcomes.
RESULTS
During the study period, rates of MRSA colonization and bacteremia were found to be 0.68% and 0.10%, respectively. No differences in demographic characteristics, mortality, and major morbidities were identified among infants with and without MRSA colonization.
CONCLUSIONS
We reported a low rate of MRSA colonization in infants admitted to our NICU, without impact on mortality and inhospital morbidity. Further large-scale studies are needed to understand the implications and cost-effectiveness of active MRSA surveillance.
背景
耐甲氧西林金黄色葡萄球菌（MRSA）是新生儿重症监护病房（NICU）患者中一种众所周知的医院病原体。关于 MRSA 定植对新生儿发病率影响的研究很少。
方法
我们对 2010 年 1 月至 2014 年 6 月期间在一家三级 NICU 出生的 MRSA 定植和非定植婴儿进行了 1:3 匹配队列研究，以回顾他们的人口统计学特征和结局。
结果
在研究期间，MRSA 定植和菌血症的发生率分别为 0.68%和 0.10%。MRSA 定植和非定植婴儿在人口统计学特征、死亡率和主要发病率方面无差异。
结论
我们报告了在我们的 NICU 中住院的婴儿中 MRSA 定植率较低，这对死亡率和住院发病率没有影响。需要进一步开展大规模研究，以了解主动 MRSA 监测的意义和成本效益。
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