6-羟基多巴胺对大鼠下丘脑去甲肾上腺素能和神经肽Y能神经支配的影响存在差异。

Noradrenaline and neuropeptide Y innervation of the rat hypothalamus are differentially affected by 6-hydroxydopamine.

作者信息

Gustafson E L, Moore R Y

机构信息

Department of Neurology, State University of New York, Stony Brook 11794.

出版信息

Neurosci Lett. 1987 Dec 16;83(1-2):53-8. doi: 10.1016/0304-3940(87)90215-1.

DOI:10.1016/0304-3940(87)90215-1

PMID:3126463

Abstract

The neuropeptide Y (NPY) innervation of the hypothalamus is thought to arise largely from noradrenaline (NA) neurons of the medullary tegmentum in the rat. This view was tested in this study by analyzing the effects of intraventricular injections of 6-hydroxydopamine (6-OHDA) on hypothalamic NA and NPY innervation. 6-OHDA markedly depletes or eliminates the NA innervation of the hypothalamus, as demonstrated by dopamine-beta-hydroxylase immunohistochemistry, but does not affect the NPY innervation of the hypothalamus. These results indicate that the hypothalamic NPY innervation arises in large part from intrinsic NPY-producing neurons rather than from medullary neurons in which NA and NPY coexist.

摘要

人们认为，大鼠下丘脑的神经肽Y（NPY）神经支配主要源自延髓被盖的去甲肾上腺素（NA）神经元。本研究通过分析脑室内注射6-羟基多巴胺（6-OHDA）对下丘脑NA和NPY神经支配的影响来验证这一观点。多巴胺-β-羟化酶免疫组织化学显示，6-OHDA能显著消耗或消除下丘脑的NA神经支配，但不影响下丘脑的NPY神经支配。这些结果表明，下丘脑的NPY神经支配在很大程度上源自内在的产生NPY的神经元，而非NA和NPY共存的延髓神经元。