高密度脂蛋白胆固醇水平低的心血管疾病患者的高密度脂蛋白亚组分。高甘油三酯血症对亚组分浓度和组成的影响。

High density lipoprotein (HDL) subfractions in cardiovascular patients with low levels of HDL-cholesterol. Influence of hypertriglyceridaemia on subfraction concentration and composition.

作者信息

Hong M L, James R W, Grab B, Pometta D

机构信息

Division de Diabétologie, Hôpital Cantonal Universitaire, Geneva, Switzerland.

出版信息

Atherosclerosis. 1988 Feb;69(2-3):241-8. doi: 10.1016/0021-9150(88)90020-2.

DOI:10.1016/0021-9150(88)90020-2

PMID:3126751

Abstract

The major high density lipoprotein (HDL) subfractions were examined in angiographically defined cardiovascular patients with low HDL-cholesterol (HDL-C) levels. The aims were to study subfraction concentration and composition, and the extent to which hypertriglyceridaemia (HTG) modified these variables. Normotriglyceridaemic (NTG)-low HDL-C patients showed similar subfraction composition to age-matched healthy controls. However, these groups showed notable differences in subfraction composition compared to HTG-low HDL-C patients, particularly with regard to the HDL2 subfraction. HDL subfraction mass was significantly reduced in both cardiovascular groups; the HTG group showed a greater reduction in HDL2, whilst the NTG group showed a greater reduction in HDL3. The major HDL apoprotein (apo A-I) was lower in both subfractions of the cardiovascular patients. Apo A-II showed significant reductions only in the HTG patients.

摘要

对血管造影确诊的高密度脂蛋白胆固醇（HDL-C）水平较低的心血管疾病患者的主要高密度脂蛋白（HDL）亚组分进行了检测。目的是研究亚组分的浓度和组成，以及高甘油三酯血症（HTG）对这些变量的影响程度。正常甘油三酯血症（NTG）-低HDL-C患者的亚组分组成与年龄匹配的健康对照相似。然而，与HTG-低HDL-C患者相比，这些组在亚组分组成上存在显著差异，特别是在HDL2亚组分方面。两个心血管疾病组的HDL亚组分质量均显著降低；HTG组的HDL2降低幅度更大，而NTG组的HDL3降低幅度更大。心血管疾病患者的两个亚组分中主要的HDL载脂蛋白（apo A-I）均较低。仅HTG患者的apo A-II显著降低。