Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland.
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
J Biomed Mater Res A. 2019 Nov;107(11):2447-2457. doi: 10.1002/jbm.a.36751. Epub 2019 Jul 22.
A surface of polymeric nonwovens may be coated with various types of nanoparticles for medical applications, filtration, and so forth. However, quite often methods used for surface modification are difficult to scale up or are not applicable for polymers. In this article, we present one-step process enabling nonwovens functionalization. Poly(l-lactide-co-glicolide) (PLGA) nonwovens were prepared by electrospinning process and coated with hydroxyapatite nanoparticles (HAp) using ultrasonic processing. The effect of the process was evaluated with various techniques. HAp layer was successfully attached without loss of structural properties of HAp or PLGA nonwovens. The analysis confirmed the decrease of hydrophobicity of coated nonwoven, as well as its biocompatibility, making this material valuable from the perspective of medical applications. The sonochemical functionalization of polymeric nonwovens may be considered as an effective and economic method, enhancing surface properties of electrospun nonwovens for various applications.
聚合物非织造布的表面可以涂覆各种类型的纳米粒子,用于医疗应用、过滤等。然而,用于表面改性的方法往往难以放大或不适用于聚合物。在本文中,我们提出了一种能够实现非织造布功能化的一步法工艺。采用静电纺丝工艺制备聚(L-丙交酯-co-乙交酯)(PLGA)非织造布,并通过超声处理在其表面涂覆羟基磷灰石纳米粒子(HAp)。采用多种技术对该工艺进行了评估。成功地在不损失 HAp 或 PLGA 非织造布结构性能的情况下,将 HAp 层附着在其表面。分析结果证实,涂覆的非织造布的疏水性降低,同时其生物相容性增强,这使得该材料在医疗应用方面具有很高的价值。聚合物非织造布的超声化学功能化可以被认为是一种有效且经济的方法,可增强静电纺丝非织造布的表面性能,从而应用于各种领域。