[健康个体中 基因与 基因甲基化水平与衰老的相关性] （你提供的原文中基因名称部分缺失，所以翻译可能不太准确，你可补充完整后让我再为你翻译）
[Correlation between methylation level of and genes and aging in healthy individuals].
作者信息
Zheng Zhonghua, Ji Huihui, Chen Chujia, Li Yin, Duan Shiwei
机构信息
Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2019 Jun 30;39(6):724-730. doi: 10.12122/j.issn.1673-4254.2019.06.15.
OBJECTIVE
To analyze the relationship between and gene methylation with aging in the general population.
METHODS
We collected peripheral blood samples from 284 male and 246 female healthy subjects for detection of methylation levels of and genes using quantitative methylation-specific PCR (qMSP). The relationship between the methylation levels of and genes and aging was analyzed using Spearman or Pearson correlation test.
RESULTS
We found a significant positive correlation between the methylation levels of the two genes in these subjects ( < 0.05). In the overall population as well in the female subjects, methylation was found to be inversely correlated with age ( < 0.05). The methylation levels of and genes were inversely correlated with TG, ApoE, Lp(a) and AST in the overall population ( < 0.05). In both the female and male subjects, the methylation levels of the two genes were inversely correlated with Lp(a) ( < 0.05). In the male subjects, methylation was inversely correlated with AST ( < 0.05), while methylation was inversely correlated with HDL and ApoE ( < 0.05). In the female subjects, methylation was positively correlated with LDL and inversely correlated with ApoE and AST ( < 0.05).
CONCLUSIONS
The methylation levels of and are closely related to age and the levels of multiple proteins in healthy subjects.
目的
分析普通人群中[具体基因名称1]和[具体基因名称2]基因甲基化与衰老之间的关系。
方法
我们收集了284名男性和246名女性健康受试者的外周血样本，采用定量甲基化特异性PCR（qMSP）检测[具体基因名称1]和[具体基因名称2]基因的甲基化水平。使用Spearman或Pearson相关检验分析[具体基因名称1]和[具体基因名称2]基因甲基化水平与衰老之间的关系。
结果
我们发现这些受试者中这两个基因的甲基化水平之间存在显著正相关（<0.05）。在总体人群以及女性受试者中，[具体基因名称1]甲基化与年龄呈负相关（<0.05）。在总体人群中，[具体基因名称1]和[具体基因名称2]基因的甲基化水平与甘油三酯（TG）、载脂蛋白E（ApoE）、脂蛋白(a) [Lp(a)]和谷草转氨酶（AST）呈负相关（<0.05）。在女性和男性受试者中，这两个基因的甲基化水平与脂蛋白(a)均呈负相关（<0.05）。在男性受试者中，[具体基因名称1]甲基化与AST呈负相关（<0.05），而[具体基因名称2]甲基化与高密度脂蛋白（HDL）和载脂蛋白E呈负相关（<0.05）。在女性受试者中，[具体基因名称1]甲基化与低密度脂蛋白（LDL）呈正相关，与载脂蛋白E和AST呈负相关（<0.05）。
结论
[具体基因名称1]和[具体基因名称2]的甲基化水平与健康受试者的年龄及多种蛋白质水平密切相关。
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