贝那鲁肽治疗重度哮喘伴嗜酸性慢性鼻-鼻窦炎高嗜酸性粒细胞血症的快速疗效。
Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis.
机构信息
Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.
Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.
出版信息
Medicina (Kaunas). 2019 Jul 3;55(7):336. doi: 10.3390/medicina55070336.
A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia.
一位 56 岁的严重哮喘男性患者接受了支气管热成形术（BT）。然而，他的哮喘恶化，2 个月后出现嗜酸性粒细胞增多症，因此需要口服皮质类固醇（OCS）治疗。BT 后 6 个月，诊断为伴有嗜酸性粒细胞性慢性鼻-鼻窦炎（ECRS）的严重哮喘，并开始使用贝那鲁肽治疗；随后血嗜酸性粒细胞计数下降，肺功能改善，从而可以逐渐减少 OCS 剂量。令人惊讶的是，贝那鲁肽不仅减少了鼻息肉，而且改善了 ECRS。因此，贝那鲁肽可能是治疗伴有 ECRS 的严重哮喘的一种有效药物，特别是在嗜酸性粒细胞增多症患者中。
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