N.K. Koltsov Institute of Developmental Biology of Russian Academy of Sciences, Vavilova str. 26, Moscow, 119334, Russia.
Trends Cell Biol. 2019 Sep;29(9):689-694. doi: 10.1016/j.tcb.2019.06.002. Epub 2019 Jul 2.
Steric hindrances by bulky histone modifications (such as ubiquitylation) could destabilize and remodel canonical nucleosome structure. This highlights a novel mechanism by which bulky modifications directly regulate chromatin, distinct from the more generally accepted roles of histone modifications in the recruitment of downstream effectors and histone charge shielding.
体积庞大的组蛋白修饰（如泛素化）产生的空间位阻可能会破坏和重塑典型核小体结构。这凸显了一种新的机制，即体积庞大的修饰物可直接调控染色质，与组蛋白修饰物在招募下游效应因子和组蛋白电荷屏蔽方面的更普遍作用不同。
