Holst Line M, Kronborg Jonas B, Idorn Lars, Bjerre Jesper V, Vejlstrup Niels, Juul Klaus, Ravn Hanne B
Department of Cardiothoracic Anaesthesia, Intensive Care Unit, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Department of Paediatric Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Cardiol Young. 2019 Aug;29(8):1082-1087. doi: 10.1017/S1047951119001604. Epub 2019 Jul 9.
To describe the impact of CHD surgery in early childhood on quality of life in children aged 10-16 years with surgically corrected Ventricular Septal Defect, Transposition of the Great Arteries, and Tetralogy of Fallot.
A cross-sectional survey study of quality of life survey on 161 children and adolescents aged 10-16 years with surgically corrected Ventricular Septal Defect, Transposition of the Great Arteries, and Tetralogy of Fallot. The international Paediatric Quality of Life 4.0 quality of life questionnaires were applied and collected for assessment from patients and parents. The endpoints were total, physical, emotional, social, and school quality of life scores.
The quality of life total and school scores was significantly lower in children with CHD than their healthy peers. There was no significant difference in quality of life between the three CHD groups. All three CHD groups had a significantly lower total (7.7-13.2%, p<0.001) and school scores (21.1-31.6%, p<0.001) than the control group. The tetralogy of Fallot group was the only group that had significantly lower scores in the physical subscale (p<0.001) than the controls.
Children and adolescents with surgically corrected CHD show losses in quality of life in total and school scores compared to healthy controls. The tetralogy of Fallot group was the only CHD group that had significantly lower physical score than the controls.
描述儿童早期冠心病手术对10 - 16岁经手术矫正室间隔缺损、大动脉转位和法洛四联症患儿生活质量的影响。
对161例年龄在10 - 16岁、经手术矫正室间隔缺损、大动脉转位和法洛四联症的儿童及青少年进行生活质量横断面调查研究。应用国际儿童生活质量4.0问卷，从患者及其父母处收集进行评估。终点指标为生活质量总分、身体、情感、社会和学校生活质量得分。
冠心病患儿的生活质量总分和学校生活质量得分显著低于健康同龄人。三组冠心病患儿的生活质量无显著差异。所有三组冠心病患儿的总分（7.7 - 13.2%，p<0.001）和学校生活质量得分（21.1 - 31.6%，p<0.001）均显著低于对照组。法洛四联症组是唯一在身体维度得分显著低于对照组的组（p<0.001）。
与健康对照组相比，经手术矫正冠心病的儿童和青少年在生活质量总分和学校生活质量得分方面有所下降。法洛四联症组是唯一身体维度得分显著低于对照组的冠心病组。
