Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 211 East Ontario Street Suite 1000, Chicago, IL 60611, USA.
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 211 East Ontario Street Suite 1000, Chicago, IL 60611, USA.
Immunol Allergy Clin North Am. 2019 Aug;39(3):403-415. doi: 10.1016/j.iac.2019.03.008. Epub 2019 May 16.
There is an important link between the upper and lower respiratory tracts whereby inflammation in one environment can influence the other. In acute rhinosinusitis, pathogen exposures are the primary driver for inflammation in the nose, which can exacerbate asthma. In chronic rhinosinusitis, a disease clinically associated with asthma, the inflammation observed is likely from a combination of an impaired epithelial barrier, dysregulated immune response, and potentially infection (or colonization) by specific pathogens. This review explores the associations between rhinosinusitis and asthma, with particular emphasis placed on the role of infections and inflammation.
上下呼吸道之间存在着重要的联系，一个环境中的炎症可以影响另一个环境。在急性鼻-鼻窦炎中，病原体暴露是引起鼻腔炎症的主要原因，而这种炎症可能会使哮喘恶化。在慢性鼻-鼻窦炎中，这种疾病与哮喘有临床关联，所观察到的炎症可能是由于上皮屏障受损、免疫反应失调以及特定病原体的潜在感染（或定植）所致。本综述探讨了鼻-鼻窦炎和哮喘之间的关联，特别强调了感染和炎症的作用。
