To investigate the difference, if any, in the quality of life (QoL) at specified intervals in patients undergoing same day discharge (SDD, ambulatory) next day discharge (NDD) after robot-assisted laparoscopic prostatectomy (RALP). Two hundred consecutive patients underwent RALP with either SDD or NDD. They completed validated pain and health-related QoL questionnaires at predefined intervals postoperatively and results were compared between the two groups. Pearson's coefficient revealed significant correlations between the time of discharge and physical well-being ( = -0.139;  = 0.005), emotional well-being (EWB) ( = -0.71;  < 0.001), functional assessment of cancer therapy-general (FACT-G) ( = -0.367;  < 0.001), functional assessment of cancer therapy-prostate (FACT-P) ( = -0.273;  < 0.001), pain severity score (PSS) ( = 0.237;  < 0.001), and pain interference score (PIS) ( = 0.214;  < 0.001). Student's -test revealed significant ( < 0.001) difference in the means of PSS, PIS, EWB, FACT-G, and FACT-P between both groups. Time of discharge was found to be an independent significant predictor ( < 0.01) of PSS and PIS. Pearson's coefficients revealed that PSS had significant correlations with age ( = -0.60;  < 0.001), body mass index ( = 0.87;  < 0.001), and console time (CT) ( = 0.63;  < 0.001). CT also correlated with the estimated blood loss ( = 0.65;  < 0.001). Patients who were discharged the same day as their RALP had lesser pain and interference in general activity scores 2 days after discharge and had better perceived overall health than patients who were discharged on postoperative day 1.