Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya, 464-8601, Japan.
Sci Rep. 2019 Jul 9;9(1):9950. doi: 10.1038/s41598-019-46240-6.
Stress is an important environmental factor influencing human behaviour and causing several mental disorders. Alterations in the structure of polysialic acid (polySia/PSA) due to genetic alterations in ST8SIA2, which encodes a polySia-synthesizing enzyme, are related to certain mental disorders. However, whether stress as an environmental factor leads to changes in polySia structure is unknown. Here we studied the effects of acute stress on polySia expression and found reductions in both the quantity and quality of polySia in the olfactory bulb and prefrontal cortex, even with short-term exposure to acute stress. The use of inhibitors for sialidase, microglia and astrocytes revealed that these declines were due to a transient action of sialidase from microglia and astrocytes in the olfactory bulb and prefrontal cortex, respectively. These data suggest that sialidase dynamically regulates polySia expression in a brain region-specific manner.
压力是影响人类行为并导致多种精神障碍的重要环境因素。由于编码多聚唾液酸合成酶的 ST8SIA2 发生遗传改变，导致多聚唾液酸（polySia/PSA）结构发生改变，与某些精神障碍有关。然而，作为环境因素的压力是否会导致多聚唾液酸结构发生变化尚不清楚。在这里，我们研究了急性压力对多聚唾液酸表达的影响，发现在短期暴露于急性压力后，嗅球和前额叶皮质中的多聚唾液酸数量和质量都减少了。使用唾液酸酶、小胶质细胞和星形胶质细胞抑制剂的研究表明，这些下降是由于嗅球和前额叶皮质中小胶质细胞和星形胶质细胞中的唾液酸酶的瞬时作用所致。这些数据表明，唾液酸酶以大脑区域特异性的方式动态调节多聚唾液酸的表达。
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