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一种计算新个体基因组预测准确性的有效方法。

An Efficient Method to Calculate Genomic Prediction Accuracy for New Individuals.

作者信息

Ferdosi Mohammad H, Connors Natalie K, Tier Bruce

机构信息

Animal Genetics and Breeding Unit, University of New England, Armidale, NSW, Australia.

出版信息

Front Genet. 2019 Jun 25;10:596. doi: 10.3389/fgene.2019.00596. eCollection 2019.

Abstract

Diagonal elements of the coefficient matrix are necessary to calculate the genomic prediction accuracy. Here an improved methodology is described, to update the inverse of the coefficient matrix () for new individuals with a genotype, with and without phenotypes. Computational performance is significantly improved by re-using parts of the coefficient matrix inverse calculations that do not change from one animal to another, in combination with updated calculations for those that do change. This method expedites calculation of accuracy for new individuals with genotypes, without re-doing the whole population, by using the previously calculated matrices.

摘要

系数矩阵的对角元素对于计算基因组预测准确性是必要的。本文描述了一种改进方法,用于更新系数矩阵()的逆,以适用于有或没有表型的具有基因型的新个体。通过重新使用系数矩阵逆计算中从一个个体到另一个个体不变的部分,并结合对那些变化部分的更新计算,显著提高了计算性能。该方法通过使用先前计算的矩阵,无需重新计算整个群体,即可加快对具有基因型的新个体的准确性计算。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f709/6603240/d31c933d88bc/fgene-10-00596-g0001.jpg

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本文引用的文献

1
Inexpensive Computation of the Inverse of the Genomic Relationship Matrix in Populations with Small Effective Population Size.
Genetics. 2016 Feb;202(2):401-9. doi: 10.1534/genetics.115.182089. Epub 2015 Nov 19.
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