靶向成人颗粒细胞瘤中的 TGFβ 通路：打开潘多拉魔盒？
Targeting TGFβ Pathway in Adult Granulosa Cell Tumor: Opening Pandora's Box?
机构信息
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario.
出版信息
Clin Cancer Res. 2019 Sep 15;25(18):5432-5434. doi: 10.1158/1078-0432.CCR-19-1605. Epub 2019 Jul 11.
Abstract
Adult granulosa cell tumor (AGCT) is a rare malignancy characterized by () mutation, an inherent component of the TGFβ pathway. Activin A, a TGFβ superfamily member, is a driver of this activity and is a potential target in AGCT..
摘要
成人颗粒细胞瘤 (AGCT) 是一种罕见的恶性肿瘤，其特征在于 () 突变，这是 TGFβ 通路的固有组成部分。激活素 A 是 TGFβ 超家族成员，是这种活性的驱动因素，也是 AGCT 的潜在靶点。
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