硼（三（五氟苯基）硼烷）催化邻醌甲基化物与重氮乙酸酯的形式（4+1）环化反应：通向2,3-二氢苯并呋喃的方法
B(CF)-Catalyzed formal (4+1)-annulation of ortho-quinone methides with diazoacetates: access to 2,3-dihydrobenzofurans.
作者信息
Xu Guangyang, Tang Shengbiao, Shao Ying, Sun Jiangtao
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
出版信息
Chem Commun (Camb). 2019 Aug 11;55(62):9096-9099. doi: 10.1039/c9cc04863d. Epub 2019 Jul 12.
PMID:31297497
Abstract
A novel (4+1)-cycloaddition reaction of alkyne-tethered ortho-quinone methides with diazoacetates has been well established by using B(CF) as the catalyst, providing 2,3-dihydrobenzofuran derivatives containing a newly formed quaternary carbon center in good yields and diastereoselectivities (up to >19 : 1 dr).
摘要
通过使用B(CF)作为催化剂，已成功建立了一种炔基连接的邻醌甲基化物与重氮乙酸酯的新型(4+1)环加成反应，能以良好的产率和非对映选择性（高达>19:1 dr）提供含有新形成的季碳中心的2,3-二氢苯并呋喃衍生物。
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