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关节镜下部分半月板切除术治疗退行性半月板撕裂 1 年和 2 年后预后不良的预测因素:奥登塞-奥斯陆半月板切除术与运动(OMEX)试验手术治疗组的二次探索性研究

Complex Tears, Extrusion, and Larger Excision Are Prognostic Factors for Worse Outcomes 1 and 2 Years After Arthroscopic Partial Meniscectomy for Degenerative Meniscal Tears: A Secondary Explorative Study of the Surgically Treated Group From the Odense-Oslo Meniscectomy Versus Exercise (OMEX) Trial.

机构信息

Department of Orthopaedic Surgery, Martina Hansens Hospital, Sandvika, Norway.

Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.

出版信息

Am J Sports Med. 2019 Aug;47(10):2402-2411. doi: 10.1177/0363546519858602. Epub 2019 Jul 12.

Abstract

BACKGROUND

Few studies have examined morphological findings from preoperative magnetic resonance imaging (MRI) and arthroscopic findings as prognostic factors for outcomes 1 and 2 years after arthroscopic partial meniscectomy (APM).

PURPOSE/HYPOTHESIS: The purpose was to evaluate prognostic factors of preoperative findings from MRI and arthroscopic evaluation on lower extremity performance at 1 year and patient-reported outcomes at 1 to 2 years after APM. The hypothesis was that medial compartment abnormalities would be prognostic for 1- and 2-year functional outcomes.

STUDY DESIGN

Cohort study; Level of evidence, 2.

METHODS

This secondary analysis from the OMEX (Odense-Oslo Meniscectomy Versus Exercise) trial included 40 patients treated surgically. Regression analyses with adjustments for age, sex, and body mass index explored associations between MRI findings (tear complexity and extrusion), arthroscopic findings (tear length, cartilage injury, and amount of excised meniscal tissue), and the following: lower extremity performance tests and thigh muscle strength at 1 year and the 5 Knee injury and Osteoarthritis Outcome Score (KOOS) subscales at 1 and 2 years.

RESULTS

A complex meniscal tear was a significant and clinically relevant prognostic factor for worse KOOS Symptoms subscores at 2 years (mean, 14.1 points [95% CI, 6.1-22.2]). Meniscal extrusion of at least 11%, 25%, and 20% were significant and clinically relevant prognostic factors for worse KOOS Activities of Daily Living (ADL) subscores at 1 year and worse KOOS Sports and Recreation (Sports/Rec) subscores at 1 and 2 years, respectively. Tear lengths of at least 7.0 mm, 6.7 mm, and 6.5 mm were significant and clinically relevant prognostic factors for better KOOS Symptoms subscores at 1 year and better KOOS Sports/Rec subscores at 1 and 2 years, respectively. A cartilage injury in the medial compartment was a significant and clinically relevant prognostic factor for worse KOOS ADL and Quality of Life (QoL) subscores at 2 years (mean, 10.4 and 19.4 points, respectively [95% CI, 3.4-17.4 and 7.7-31.1, respectively]). More than 20% meniscal tissue excised was a significant and clinically relevant prognostic factor for worse KOOS Pain, Symptoms, ADL, and Sports/Rec subscores at 1 and 2 years (mean, 8.9-41.5 points [95% CI, 2.2-15.5 to 21.0-62.0]) and worse KOOS QoL subscores at 2 years (mean, 25.3 points [95% CI, 13.6-37.0]).

CONCLUSION

Complex meniscal tears, larger extrusion, cartilage injuries, and larger meniscal excision were significant and clinically relevant prognostic factors for worse outcomes 1 and 2 years after APM.

REGISTRATION

NCT01002794 (ClinicalTrials.gov identifier).

摘要

背景

很少有研究探讨过关节镜检查前磁共振成像(MRI)的形态学发现和关节镜检查发现作为关节镜部分半月板切除术(APM)后 1 年和 2 年结局的预后因素。

目的/假设:本研究旨在评估 MRI 和关节镜评估的术前发现对 APM 后 1 年下肢功能和 1 至 2 年患者报告结局的预后因素。假设内侧间室异常将是 1 年和 2 年功能结局的预后因素。

研究设计

队列研究;证据水平,2 级。

方法

这是来自 OMEX(奥登塞-奥斯陆半月板切除术与运动)试验的二次分析,包括 40 名接受手术治疗的患者。回归分析调整了年龄、性别和体重指数,以探讨 MRI 发现(撕裂复杂性和挤出)、关节镜发现(撕裂长度、软骨损伤和切除的半月板组织量)与以下方面之间的关系:1 年时的下肢功能测试和大腿肌肉力量,以及 1 年和 2 年时的 5 膝关节损伤和骨关节炎结果评分(KOOS)子量表。

结果

复杂半月板撕裂是 2 年时 KOOS 症状子量表较差的显著且具有临床意义的预后因素(平均 14.1 分[95%CI,6.1-22.2])。半月板挤出至少 11%、25%和 20%分别是 1 年时 KOOS 日常生活活动(ADL)子量表和 1 年和 2 年时 KOOS 运动和娱乐(Sports/Rec)子量表较差的显著且具有临床意义的预后因素。撕裂长度至少 7.0、6.7 和 6.5 毫米分别是 1 年时 KOOS 症状子量表和 1 年和 2 年时 KOOS Sports/Rec 子量表更好的显著且具有临床意义的预后因素。内侧间室的软骨损伤是 2 年时 KOOS ADL 和生活质量(QoL)子量表较差的显著且具有临床意义的预后因素(平均分别为 10.4 和 19.4 分[95%CI,3.4-17.4 和 7.7-31.1])。切除的半月板组织超过 20%是 1 年和 2 年时 KOOS 疼痛、症状、ADL 和 Sports/Rec 子量表较差的显著且具有临床意义的预后因素(平均分别为 8.9-41.5 分[95%CI,2.2-15.5 至 21.0-62.0])和 2 年时 KOOS QoL 子量表较差的显著且具有临床意义的预后因素(平均 25.3 分[95%CI,13.6-37.0])。

结论

复杂半月板撕裂、较大的挤出、软骨损伤和更大的半月板切除是 APM 后 1 年和 2 年结局较差的显著且具有临床意义的预后因素。

登记

NCT01002794(ClinicalTrials.gov 标识符)。

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