成年人多发性硬化症患者一生中的身体活动和行走表现。

Physical activity and walking performance across the lifespan among adults with multiple sclerosis.

机构信息

Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA; University of Alabama at Birmingham Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.

出版信息

Mult Scler Relat Disord. 2019 Oct;35:36-41. doi: 10.1016/j.msard.2019.07.003. Epub 2019 Jul 4.

DOI:10.1016/j.msard.2019.07.003

PMID:31302502

Abstract

BACKGROUND

There is consistent evidence of an association between physical activity and walking performance in persons with multiple sclerosis (MS). To date, this relationship has been predominantly examined in young and middle-aged adults rather than in the rapidly-growing population of older adults with MS who often times have greater walking problems and are less physically active. This study examined whether physical activity was differentially associated with walking performance across three age groups of young (20-39 years), middle-aged (40-59 years), and older (60-79 years) adults with MS.

METHODS

The sample included 124 persons with MS who attended one testing session and provided demographic information, completed the Timed 25-Foot Walk (T25FW) and the Six Minute Walk (6MW) as measures of walking speed and walking endurance, respectively, and wore an accelerometer for a 7-day period.

RESULTS

Trend analysis indicated light physical activity did not significantly differ with increasing age; however, moderate-to-vigorous physical activity (MVPA), walking speed, and walking endurance declined with increasing age. Partial spearman's rank-order correlations between physical activity and walking outcomes that controlled for disease duration, race, and ambulatory disability within each age group indicated that the relationship between MVPA and walking performance was strong among older adults with MS (pr for MVPA and T25FW: young = -0.01, middle-aged = -0.16, older = -0.63*; pr for MVPA and 6MW: young = 0.10, middle-aged = 0.08, older = 0.68*).

CONCLUSION

Interventions targeting MVPA may be an appropriate approach for managing walking impairment, particularly in older adults with MS.

摘要

背景

有大量证据表明体力活动与多发性硬化症（MS）患者的行走表现之间存在关联。迄今为止，这种关系主要在年轻和中年成年人中进行了检查，而在多发性硬化症的快速增长的老年人群中却很少见，这些老年人通常有更多的行走问题，身体活动也较少。本研究检查了体力活动是否与三个年龄组（20-39 岁、40-59 岁和 60-79 岁）的多发性硬化症年轻、中年和老年成年人的行走表现存在差异。

方法

该样本包括 124 名参加了一次测试会议的多发性硬化症患者，提供了人口统计学信息，分别完成了定时 25 英尺步行（T25FW）和 6 分钟步行（6MW）测试，作为行走速度和行走耐力的测量指标，并佩戴加速度计进行了 7 天的测试。

结果

趋势分析表明，轻度体力活动与年龄的增加没有显著差异；然而，中度到剧烈的体力活动（MVPA）、行走速度和行走耐力随年龄的增加而下降。在每个年龄组中，控制疾病持续时间、种族和步行能力的部分 Spearman 等级相关分析表明，MVPA 与老年人多发性硬化症患者的行走表现之间存在较强的关系（MVPA 和 T25FW 的 pr：年轻= -0.01，中年= -0.16，老年= -0.63*；MVPA 和 6MW 的 pr：年轻= 0.10，中年= 0.08，老年= 0.68*）。