Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Medical Physics, Uppsala University Hospital, Uppsala, Sweden; and.
J Nucl Med. 2020 Feb;61(2):217-221. doi: 10.2967/jnumed.119.228072. Epub 2019 Jul 13.
PET/CT with Ga-DOTA-somatostatin analogs has been tested for therapy monitoring in patients with neuroendocrine tumors (NETs). However, SUVs in tumors do not correlate with the net influx rate (K), as a representation of the somatostatin receptor expression. In this study, tumor-to-blood ratio (TBR) was evaluated as an alternative tool for semiquantitative assessment of Ga-DOTATOC and Ga-DOTATATE tumor uptake and as a therapy monitoring tool for patients with NETs. Twenty-two NET patients underwent a 45-min dynamic PET/CT scan after injection of Ga-DOTATOC or Ga-DOTATATE. K was determined using the Patlak method, and TBR was calculated for the 40- to 45-min interval. A linear relation was found between K and TBR, with a square of Pearson correlation of 0.98 and 0.93 for Ga-DOTATOC and Ga-DOTATATE, respectively. A high correlation was found between K and TBR. Hence, TBR reflects somatostatin receptor density more accurately than SUV and is suggested as the preferred metric for semiquantitative assessment of Ga-DOTATOC and Ga-DOTATATE tumor uptake.
正电子发射断层扫描/计算机断层扫描（PET/CT）结合镓-DOTA-生长抑素类似物已用于神经内分泌肿瘤（NETs）的治疗监测。然而，肿瘤的标准摄取值（SUV）与作为生长抑素受体表达的代表的净摄取率（K）不相关。在这项研究中，肿瘤与血比值（TBR）被评估为评估 Ga-DOTATOC 和 Ga-DOTATATE 肿瘤摄取的半定量的替代工具，也是 NET 患者的治疗监测工具。22 名 NET 患者在注射 Ga-DOTATOC 或 Ga-DOTATATE 后进行了 45 分钟的动态 PET/CT 扫描。使用 Patlak 方法确定 K，计算 40-45 分钟间隔的 TBR。发现 K 与 TBR 之间存在线性关系，Ga-DOTATOC 和 Ga-DOTATATE 的 Pearson 相关系数平方分别为 0.98 和 0.93。K 与 TBR 之间存在高度相关性。因此，TBR 比 SUV 更能准确地反映生长抑素受体密度，建议将其作为 Ga-DOTATOC 和 Ga-DOTATATE 肿瘤摄取的半定量评估的首选指标。
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