Yuan Yishu, Zhu Wei, Gong Guanghui, Jiang Jing, Wang Yixuan, Wu Xiaoying
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Pathology, School of Basic Medical Science, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 May 28;44(5):528-534. doi: 10.11817/j.issn.1672-7347.2019.05.009.
To explore the role of P53, pairing box gene 8 antibody (PAX8), and calcium omentum protein (Calretinin) in the origin of epithelial ovarian cancer. Methods: A total of 63 tissue samples of ovarian tumor and fallopian tubes were collected. Immunohistochemistry methods were used to analyze the expression of P53, PAX8, and Calretinin. The relationship between these protein levels and the classification of ovarian tumors was evaluated. Results: In epithelial ovarian cancer, the P53 or PAX8 was correlated with the occurrence of high-grade carcinoma, while the calretinin was correlated with the occurrence of low-grade carcinoma (P<0.05). The combination of PAX8 with Calretinin was correlated with the grade of ovarian tumor (P<0.05). The combination of P53 with Calretinin was correlated with the grade of tumor (P<0.05). The combination of P53 with PAX8 was correlated with the grade of tumor (P<0.05). The expression of P53 in fallopian tubes was correlated with the malignant degree of epithelial ovarian cancer (P<0.05). The degree of fallopian tube lesions in patients with ovarian cancer was correlated with epithelial ovarian cancer. The malignant lesions of tubal epithelium was correlated with high-grade carcinoma, while the normal or atypical hyperplasia of tubal epithelium was correlated with low-grade carcinoma (P<0.05). Conclusion: P53 and Calretinin combined with PAX8 show a synergistic effect on the differentiation of epithelial ovarian cancer grade. The morphology of HE and the expression of TP53 in the fallopian tube epithelium play an auxiliary role in the diagnosis of epithelial ovarian cancer.
探讨P53、配对盒基因8抗体（PAX8）和钙网膜蛋白（Calretinin）在上皮性卵巢癌起源中的作用。方法：收集63例卵巢肿瘤及输卵管组织样本。采用免疫组织化学方法分析P53、PAX8和Calretinin的表达情况。评估这些蛋白水平与卵巢肿瘤分类之间的关系。结果：在上皮性卵巢癌中，P53或PAX8与高级别癌的发生相关，而Calretinin与低级别癌的发生相关（P<0.05）。PAX8与Calretinin的联合表达与卵巢肿瘤分级相关（P<0.05）。P53与Calretinin的联合表达与肿瘤分级相关（P<0.05）。P53与PAX8的联合表达与肿瘤分级相关（P<0.05）。输卵管中P53的表达与上皮性卵巢癌的恶性程度相关（P<0.05）。卵巢癌患者的输卵管病变程度与上皮性卵巢癌相关。输卵管上皮的恶性病变与高级别癌相关，而输卵管上皮的正常或非典型增生与低级别癌相关（P<0.05）。结论：P53和Calretinin联合PAX8对上皮性卵巢癌分级的分化具有协同作用。HE形态及输卵管上皮中TP53的表达在上皮性卵巢癌诊断中起辅助作用。
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