Multi-scale biological and physical modelling of the tumour micro-environment.

Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) interaction and transport biochemistry, and, (4) methods for scaling to physiologically representative numbers of cells. In this article, our interest is the modelling of the tumour micro-environment. We review the broader area of cell-scale resolving blood flow modelling, while focusing on the particular interactions of tumour cells and white blood cells, known to play an important role in metastasis.