中毒性神经病：化疗诱导的周围神经病。
Toxic neuropathies: Chemotherapy Induced Peripheral Neurotoxicity.
机构信息
Experimental Neurology Unit, School of Medicine and Surgery, University Milano Bicocca, Monza and NeuroMI (Milan Center for Neuroscience), Milan, Italy.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Curr Opin Neurol. 2019 Oct;32(5):676-683. doi: 10.1097/WCO.0000000000000724.
PURPOSE OF REVIEW
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common and distressing side-effect of many chemotherapy regimens. Currently, aside from symptomatic treatments for neuropathic pain, there are no treatments to prevent CIPN or treat established CIPN. We discuss recent articles addressing clinimetric issues and treatment of CIPN.
RECENT FINDINGS
There are important clinimetric issues that need to be addressed so that robust clinical trials in CIPN can be performed. There are new compounds in early development that may treat CIPN, but larger studies are needed.
SUMMARY
A multidisciplinary, international approach is needed to unravel CIPN; the Toxic Neuropathy Consortium (TNC) of the Peripheral Nerve Society may be the home for such efforts.
目的综述
化疗引起的周围神经毒性（CIPN）是许多化疗方案常见且令人痛苦的副作用。目前，除了针对神经病理性疼痛的对症治疗外，尚无预防 CIPN 或治疗已确立的 CIPN 的方法。我们讨论了最近有关临床测量问题和 CIPN 治疗的文章。
最近的发现
有一些重要的临床测量问题需要解决，以便在 CIPN 中进行稳健的临床试验。目前正在早期开发一些新的化合物，这些化合物可能对 CIPN 有效，但需要进行更大规模的研究。
总结
需要采用多学科、国际化的方法来解决 CIPN 问题；周围神经学会的毒理神经学联合会（TNC）可能是此类研究的合适平台。
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