Discipline of Child and Adolescent Health, Faculty of Health and Medicine, The University of Sydney, Sydney, Australia; Heart Centre for Children, The Children's Hospital at Westmead, Westmead, Australia.
Curtin University School of Public Health, Perth, Australia.
Semin Thorac Cardiovasc Surg. 2020 Spring;32(1):108-116. doi: 10.1053/j.semtcvs.2019.07.004. Epub 2019 Jul 12.
Biventricular repair of complete atrioventricular septal defect (CAVSD) is largely achieved using the double-patch (DP) or modified single-patch (MSP) techniques in the current era; however, long-term results following MSP repair are not well defined. We aimed to compare long-term outcomes including reoperation and mortality after CAVSD repair using DP and MSP techniques, and identify the risk factors associated with adverse outcomes. A retrospective cohort study was performed including all patients who underwent CAVSD repair using DP and MSP techniques at our institution between 17 May 1990 and 14 December 2015. Demographic details, early (≤30 days) and late (>30 days) outcomes (reoperation, mortality) were studied. Competing risks analysis with cumulative incidence function was used for survival analyses. Overall, 273 consecutive patients underwent CAVSD repair (120 DP and 153 MSP) and 41 patients required reoperation during follow-up. Competing risks analysis showed no association between repair technique and reoperation (P = 1.0) or mortality (P = 0.9). Considering competing risks due to mortality, the cumulative incidence of reoperation at 5, 10, and 15 years was 14%, 17%, and 17% for DP and 12%, 13%, and 16% for MSP, respectively. Non-Down syndrome and moderate or greater left atrioventricular valve regurgitation were predictors for reoperation. Pulmonary artery banding was predictive of mortality, though strongly associated with earlier surgical era. Median follow-up duration was 8.0 years (interquartile range 3.9-20.8) for DP and 11.6 years (interquartile range 5.4-16.1) for MSP (P = 0.4). Event-free survival is similar after DP and MSP repair of CAVSD indicating either repair technique can be safely utilized.
双心室修复完全性房室间隔缺损(CAVSD)在当前时代主要采用双补片(DP)或改良单补片(MSP)技术;然而,MSP 修复后的长期结果尚不清楚。我们旨在比较使用 DP 和 MSP 技术修复 CAVSD 后的长期结果,包括再次手术和死亡率,并确定与不良结果相关的风险因素。回顾性队列研究包括 1990 年 5 月 17 日至 2015 年 12 月 14 日期间在我院接受 DP 和 MSP 技术修复 CAVSD 的所有患者。研究了人口统计学细节、早期(≤30 天)和晚期(>30 天)结果(再次手术、死亡率)。使用累积发生率函数进行竞争风险分析进行生存分析。总体而言,273 例连续患者接受了 CAVSD 修复(120 例 DP 和 153 例 MSP),随访期间有 41 例患者需要再次手术。竞争风险分析显示修复技术与再次手术(P=1.0)或死亡率(P=0.9)之间无关联。考虑到由于死亡率而产生的竞争风险,DP 的 5 年、10 年和 15 年再次手术的累积发生率分别为 14%、17%和 17%,MSP 分别为 12%、13%和 16%。非唐氏综合征和中重度或以上左房室瓣反流是再次手术的预测因素。肺动脉带缩术是死亡率的预测因素,但与早期手术时代密切相关。DP 的中位随访时间为 8.0 年(四分位间距 3.9-20.8),MSP 为 11.6 年(四分位间距 5.4-16.1)(P=0.4)。DP 和 MSP 修复 CAVSD 后的无事件生存情况相似,表明两种修复技术均可安全使用。