环状 RNA circHIPK3 作为一个预后标志物促进慢性髓性白血病的进展。
Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression.
机构信息
Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
出版信息
Neoplasma. 2020 Jan;67(1):171-177. doi: 10.4149/neo_2018_181129N908. Epub 2019 Jun 28.
Increasing evidence demonstrate that circular RNAs (circRNAs) play critical role in regulation of gene expression, which participate in the pathogenesis of cancer, including chronic myeloid leukemia (CML). In this study, we aimed to investigate the expression profiling of circHIPK3 in CML. We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. High circHIPK3 expression predicted a poor outcome of CML patients. Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. Our findings provide insights on the role of circHIPK3 in the development and treatment of CML.
越来越多的证据表明，环状 RNA（circRNA）在基因表达调控中发挥着关键作用，它们参与了癌症的发病机制，包括慢性髓系白血病（CML）。在这项研究中，我们旨在研究 circHIPK3 在 CML 中的表达谱。我们发现，与健康对照组相比，circHIPK3 在 CML 患者的外周血单核细胞（PBMC）和血清样本中显著上调。circHIPK3 高表达预示着 CML 患者的预后不良。进一步的功能丧失实验表明 circHIPK3 在 CML 中具有致癌作用。我们的研究结果为 circHIPK3 在 CML 的发生和治疗中的作用提供了新的见解。
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