Department of Physiology, Development & Neuroscience, University of Cambridge, UK.
Centre for Trophoblast Research, University of Cambridge, UK.
BMJ. 2019 Jul 15;366:l2381. doi: 10.1136/bmj.l2381.
Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical presentation is highly variable but hypertension and proteinuria are usually seen. These systemic signs arise from soluble factors released from the placenta as a result of a response to stress of syncytiotrophoblast. There are two sub-types: early and late onset pre-eclampsia, with others almost certainly yet to be identified. Early onset pre-eclampsia arises owing to defective placentation, whilst late onset pre-eclampsia may center around interactions between normal senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease. The causes, placental and maternal, vary among individuals. Recent research has focused on placental-uterine interactions in early pregnancy. The aim now is to translate these findings into new ways to predict, prevent, and treat pre-eclampsia.
子痫前期是一种常见的疾病，尤其影响初产妇。其临床表现高度可变，但通常可见高血压和蛋白尿。这些全身症状是由合体滋养层对压力反应而从胎盘释放的可溶性因子引起的。有两种亚型：早发型和晚发型子痫前期，其他亚型几乎肯定尚未确定。早发型子痫前期是由于胎盘形成不良引起的，而晚发型子痫前期可能围绕胎盘正常衰老与母体患心血管和代谢疾病的遗传易感性之间的相互作用。其病因、胎盘和母体在个体之间存在差异。最近的研究集中在妊娠早期的胎盘-子宫相互作用。现在的目标是将这些发现转化为预测、预防和治疗子痫前期的新方法。
