一只幼猫出现慢性支气管肺炎，病因是β-肌聚糖缺乏性肌营养不良。
Beta-sarcoglycan-deficient muscular dystrophy presenting as chronic bronchopneumonia in a young cat.
作者信息
Bouillon Juliette, Taylor Suzanne M, Vargo Cheryl, Lange Michelle, Zwicker Lesley A, Sukut Sally L, Guo Ling T, Shelton G Diane
机构信息
Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Martensville Veterinary Hospital, Martensville, Saskatchewan, Canada.
出版信息
JFMS Open Rep. 2019 Jul 1;5(2):2055116919856457. doi: 10.1177/2055116919856457. eCollection 2019 Jul-Dec.
CASE SUMMARY
A 5-month-old cat was evaluated for a 3 week history of cough, nasal discharge, decreased appetite and weight loss. Musculoskeletal examination was normal and serum creatine kinase (CK) activity was within the reference interval. The cat was treated during the next 10 months for chronic, persistent pneumonia. Weakness then became apparent, the cat developed dysphagia and was euthanized. Post-mortem evaluation revealed chronic aspiration pneumonia and muscular dystrophy associated with beta (β)-sarcoglycan deficiency.
RELEVANCE AND NOVEL INFORMATION
This is the first report of a cat with muscular dystrophy presenting for chronic pneumonia without obvious megaesophagus, dysphagia or prominent neuromuscular signs until late in the course of the disease. The absence of gait abnormalities, marked muscle atrophy or hypertrophy and normal serum CK activity delayed the diagnosis in this cat with β-sarcoglycan deficiency.
病例摘要
一只5个月大的猫因咳嗽、流鼻涕、食欲减退和体重减轻3周的病史接受评估。肌肉骨骼检查正常，血清肌酸激酶（CK）活性在参考区间内。在接下来的10个月里，这只猫因慢性持续性肺炎接受治疗。随后出现虚弱，猫发展为吞咽困难并实施了安乐死。尸检评估显示慢性误吸性肺炎和与β（β）-肌聚糖缺乏相关的肌肉营养不良。
相关性及新信息
这是首例患有肌肉营养不良的猫，在疾病后期才出现慢性肺炎，而无明显的巨食管、吞咽困难或明显的神经肌肉体征。步态异常、明显的肌肉萎缩或肥大的缺失以及血清CK活性正常，延误了这只患有β-肌聚糖缺乏症猫的诊断。
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