Emerg Infect Dis. 2019 Aug;25(8):1469-1476. doi: 10.3201/eid2508.180298.
Syphilis is a sexually transmitted infection that has direct adverse effects on maternal and infant health through vertical Treponema pallidum transmission during early pregnancy. We evaluated congenital syphilis as a predictor of the quality of basic maternal and child healthcare in Brazil during 2010-2015. We investigated case rates and correlations with epidemiologic and socioeconomic indicators. We observed rising congenital syphilis incidence rates and increasing syphilis-associated perinatal and infant mortality rates in all regions. Case rates were highest in the Northeast, Southeast, and South, and congenital syphilis infant mortality rates were highest in the Northeast and Southeast. We observed correlations between congenital syphilis rates and infant death, spontaneous abortion (miscarriage), and stillbirth rates. We also noted correlations between rates of stillbirth caused by syphilis and inadequate prenatal care. Our study suggests gaps in basic healthcare for pregnant women and indicates the urgent need for measures to increase early diagnosis and appropriate treatment.
梅毒是一种性传播感染,如果孕妇在妊娠早期经垂直传播感染苍白密螺旋体,将会直接对母婴健康造成不良影响。我们评估了先天性梅毒作为 2010-2015 年巴西基本母婴保健质量的预测指标。我们调查了病例发生率,并分析了与流行病学和社会经济指标的相关性。我们观察到所有地区的先天性梅毒发病率都在上升,与梅毒相关的围产期和婴儿死亡率也在上升。病例发生率最高的是东北地区、东南部地区和南部地区,而先天性梅毒婴儿死亡率最高的是东北地区和东南部地区。我们观察到先天性梅毒发生率与婴儿死亡、自然流产(流产)和死产率之间存在相关性。我们还注意到由梅毒引起的死产率与产前保健不足之间存在相关性。我们的研究表明孕妇基本医疗保健存在差距,并表明迫切需要采取措施提高早期诊断和适当治疗。