新型大环内酯类药物氟红霉素对呼吸道病原体的抗菌活性比较
Comparative antimicrobial activity of the new macrolide flurithromycin against respiratory pathogens.
作者信息
Nord C E, Lindmark A, Persson I
机构信息
Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Sweden.
出版信息
Eur J Clin Microbiol Infect Dis. 1988 Feb;7(1):71-3. doi: 10.1007/BF01962180.
The activity of flurithromycin against Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes, Branhamella catarrhalis and Staphylococcus aureus was determined by the agar dilution method. Flurithromycin showed high activity against Streptococcus pneumoniae, Streptococcus pyogenes and Branhamella catarrhalis (MIC90 = 0.032-0.25 mg/l). Its MIC90 value against Haemophilus influenzae strains was 4.0 mg/l and 16 mg/l against Staphylococcus aureus strains. Flurithromycin has promising antibacterial activity which warrants clinical trials.
采用琼脂稀释法测定了氟红霉素对流感嗜血杆菌、肺炎链球菌、化脓性链球菌、卡他布兰汉菌和金黄色葡萄球菌的活性。氟红霉素对肺炎链球菌、化脓性链球菌和卡他布兰汉菌表现出高活性（MIC90 = 0.032 - 0.25毫克/升）。其对流感嗜血杆菌菌株的MIC90值为4.0毫克/升，对金黄色葡萄球菌菌株为16毫克/升。氟红霉素具有有前景的抗菌活性，值得进行临床试验。
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