D'Aquila Paolo S, Galistu Adriana
Dipartimento di Scienze Biomediche, Università di Sassari, Viale San Pietro 43/b, 07100, Sassari, Italy.
Dipartimento di Scienze Biomediche, Università di Sassari, Viale San Pietro 43/b, 07100, Sassari, Italy.
Behav Brain Res. 2019 Nov 5;373:112088. doi: 10.1016/j.bbr.2019.112088. Epub 2019 Jul 17.
A previous study investigating the effects of dopamine receptor antagonists administered before the first of two 24-h apart forced swim test (FST) sessions, provided evidence suggesting that evaluation of response efficacy - dependent on dopamine D-like receptors - might play a role in setting the balance between active behaviours and immobility in this test. Regardless of the underlying mechanisms, the observation that the effects of drugs in the first session have consequences in the second session might be relevant for a better understanding of the FST in behavioural/functional terms. Thus, the first objective of this study was to investigate the consequences in the second session of the administration of the prototypic antidepressant drug imipramine before the first of two sessions. A second objective was to investigate the effect of dopamine D-like and D-like receptor blockade on the effects of imipramine. Imipramine (20 mg/kg) was administered 24-h, 6-h and 30-min before the first of two FST sessions performed 24-h apart. SCH 23390 (0.01, 0.04 mg/kg) or raclopride (0.0125, 0.25 mg/kg) were administered 30-min before the first session. Imipramine increased active behaviours both in the first and in the second session. Raclopride attenuated and SCH 23390 potentiated imipramine effects only in the first session and to a limited extent. These results show that imipramine administration before the first of two FST sessions induces an increase in active behaviours in the second session, and suggest that this effect is the consequence of the behavioural effects of imipramine in the first session.
先前有一项研究，调查了在间隔24小时的两次强迫游泳试验（FST）的第一次试验之前给予多巴胺受体拮抗剂的效果，该研究提供的证据表明，依赖多巴胺D样受体的反应效能评估可能在该试验中主动行为和不动之间的平衡设定中发挥作用。无论潜在机制如何，药物在第一次试验中的效果会在第二次试验中产生影响这一观察结果，可能有助于从行为/功能角度更好地理解FST。因此，本研究的第一个目标是调查在两次试验中的第一次试验之前给予原型抗抑郁药物丙咪嗪，在第二次试验中会产生什么后果。第二个目标是研究多巴胺D样和D样受体阻断对丙咪嗪效果的影响。在间隔24小时进行的两次FST试验的第一次试验前24小时、6小时和30分钟给予丙咪嗪（20mg/kg）。在第一次试验前30分钟给予SCH 23390（0.01、0.04mg/kg）或雷氯必利（0.0125、0.25mg/kg）。丙咪嗪在第一次和第二次试验中均增加了主动行为。雷氯必利仅在第一次试验中有限地减弱了丙咪嗪的效果，而SCH 23390则增强了其效果。这些结果表明，在两次FST试验中的第一次试验之前给予丙咪嗪会导致第二次试验中的主动行为增加，并表明这种效果是丙咪嗪在第一次试验中的行为效果的结果。
