Effect of some new prostaglandin synthetase inhibitors on the endotoxin induced mortality and biochemical changes in experimental animals.

The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All the three compounds included in this report, namely isoxicam, fentiazac and ketoprofen have been found to produce significant protection against the endotoxin mortality in mice. Isoxicam and fentiazac have been found effective in antagonizing some of the biochemical changes induced by endotoxin in rats. On the other hand isoxicam and ketoprofen exacerbated the increase in serum aminotransferases induced by endotoxin. It is suggested that mechanisms other than the prostaglandin synthetase inhibition may be involved in the protective effect of these drugs.