再次手术甲状旁腺手术中的近红外成像：冷冻保存甲状旁腺的自发荧光首次描述
Near-infrared imaging in re-operative parathyroid surgery: first description of autofluorescence from cryopreserved parathyroid glands.
作者信息
Moore Edwina C, Rudin Anthony, Alameh Anas, Berber Eren
机构信息
Department of Endocrine Surgery, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Gland Surg. 2019 Jun;8(3):283-286. doi: 10.21037/gs.2018.12.05.
Abstract
Identification of parathyroid glands is one of the primary tenets in endocrine surgery. Multiple localizing techniques have been described and are in use in routine practice. More recently near-infra red imaging has been gaining popularity and is used for identification in real time. Parathyroid glands are unique in that they fluoresce when excited by near-infrared light, without the use of a biomarker. This is called autofluorescence (AF). In this case report we describe the presence of persistent AF by thawed parathyroid glands which have previously been cryopreserved. We confirm that the mechanism behind AF involves an intrinsic primary fluorophore, unique to parathyroid glands.
摘要
甲状旁腺的识别是内分泌外科的主要原则之一。已经描述了多种定位技术并在常规实践中使用。最近，近红外成像越来越受欢迎，并用于实时识别。甲状旁腺的独特之处在于，在不使用生物标志物的情况下，当被近红外光激发时它们会发出荧光。这被称为自发荧光（AF）。在本病例报告中，我们描述了先前已冷冻保存的解冻甲状旁腺中持续存在的自发荧光。我们证实自发荧光背后的机制涉及一种甲状旁腺特有的内在初级荧光团。
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