再次手术甲状旁腺手术中的近红外成像：冷冻保存甲状旁腺的自发荧光首次描述
Near-infrared imaging in re-operative parathyroid surgery: first description of autofluorescence from cryopreserved parathyroid glands.
作者信息
Moore Edwina C, Rudin Anthony, Alameh Anas, Berber Eren
机构信息
Department of Endocrine Surgery, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Gland Surg. 2019 Jun;8(3):283-286. doi: 10.21037/gs.2018.12.05.
Abstract
Identification of parathyroid glands is one of the primary tenets in endocrine surgery. Multiple localizing techniques have been described and are in use in routine practice. More recently near-infra red imaging has been gaining popularity and is used for identification in real time. Parathyroid glands are unique in that they fluoresce when excited by near-infrared light, without the use of a biomarker. This is called autofluorescence (AF). In this case report we describe the presence of persistent AF by thawed parathyroid glands which have previously been cryopreserved. We confirm that the mechanism behind AF involves an intrinsic primary fluorophore, unique to parathyroid glands.
摘要
甲状旁腺的识别是内分泌外科的主要原则之一。已经描述了多种定位技术并在常规实践中使用。最近，近红外成像越来越受欢迎，并用于实时识别。甲状旁腺的独特之处在于，在不使用生物标志物的情况下，当被近红外光激发时它们会发出荧光。这被称为自发荧光（AF）。在本病例报告中，我们描述了先前已冷冻保存的解冻甲状旁腺中持续存在的自发荧光。我们证实自发荧光背后的机制涉及一种甲状旁腺特有的内在初级荧光团。
相似文献
1
Near-infrared imaging in re-operative parathyroid surgery: first description of autofluorescence from cryopreserved parathyroid glands.再次手术甲状旁腺手术中的近红外成像：冷冻保存甲状旁腺的自发荧光首次描述
Gland Surg. 2019 Jun;8(3):283-286. doi: 10.21037/gs.2018.12.05.
2
Effects of excitation light intensity on parathyroid autofluorescence with a novel near-infrared fluorescence imaging system: two surgical case reports.新型近红外荧光成像系统中激发光强度对甲状旁腺自发荧光的影响：两例手术病例报告
Gland Surg. 2020 Oct;9(5):1584-1589. doi: 10.21037/gs-20-386.
3
Near-infrared fluorescent imaging techniques for the detection and preservation of parathyroid glands during endocrine surgery.用于内分泌手术中甲状旁腺检测与保留的近红外荧光成像技术
Innov Surg Sci. 2021 Jul 30;7(3-4):87-98. doi: 10.1515/iss-2021-0001. eCollection 2022 Dec.
4
Near-infrared autofluorescence in thyroid and parathyroid surgery.甲状腺和甲状旁腺手术中的近红外自体荧光
Gland Surg. 2020 Feb;9(Suppl 2):S136-S146. doi: 10.21037/gs.2020.01.04.
5
Intraoperative near-infrared autofluorescence imaging of parathyroid glands.甲状旁腺的术中近红外自发荧光成像
Surg Endosc. 2017 Aug;31(8):3140-3145. doi: 10.1007/s00464-016-5338-3. Epub 2016 Nov 14.
6
Intraoperative verification of parathyroid glands in primary and secondary hyperparathyroidism using near-infrared autofluorescence (IOPA).应用近红外自体荧光法（IOPA）对原发性和继发性甲状旁腺功能亢进症中的甲状旁腺进行术中验证。
Updates Surg. 2019 Sep;71(3):579-585. doi: 10.1007/s13304-019-00652-1. Epub 2019 Apr 3.
7
Parathyroid Autofluorescence-How Does It Affect Parathyroid and Thyroid Surgery? A 5 Year Experience.甲状旁腺自发荧光——它如何影响甲状旁腺和甲状腺手术？5 年经验。
Molecules. 2019 Jul 14;24(14):2560. doi: 10.3390/molecules24142560.
8
Intraoperative Parathyroid Autofluorescence Detection in Patients with Primary Hyperparathyroidism.原发性甲状旁腺功能亢进症患者术中甲状旁腺自发荧光检测。
Ann Surg Oncol. 2019 Apr;26(4):1142-1148. doi: 10.1245/s10434-019-07161-w. Epub 2019 Jan 23.
9
Intraoperative real-time localization of parathyroid gland with near infrared fluorescence imaging.近红外荧光成像技术在甲状旁腺术中实时定位的应用
Gland Surg. 2017 Oct;6(5):516-524. doi: 10.21037/gs.2017.05.08.
10
Autofluorescence in Parathyroidectomy: Signal Intensity Correlates with Serum Calcium and Parathyroid Hormone but Routine Clinical Use is Not Justified.甲状旁腺切除术的自体荧光：信号强度与血清钙和甲状旁腺激素相关，但常规临床应用没有依据。
World J Surg. 2019 Jun;43(6):1532-1537. doi: 10.1007/s00268-019-04929-9.
引用本文的文献
1
Near-Infrared Autofluorescence Signatures of Single- vs Multigland Disease in Primary Hyperparathyroidism.原发性甲状旁腺功能亢进中单发性与多发性腺体疾病的近红外自体荧光特征。
JAMA Otolaryngol Head Neck Surg. 2024 Nov 1;150(11):979-985. doi: 10.1001/jamaoto.2024.3095.
2
Why does diseased parathyroid appear weak or heterogenous intensity during intraoperative near-infrared autofluorescence?为什么在术中近红外自体荧光成像时，病变甲状旁腺的强度会变弱或出现异质性？
Front Endocrinol (Lausanne). 2023 Sep 4;14:1233610. doi: 10.3389/fendo.2023.1233610. eCollection 2023.
3
Converting a probe-based fluorescence system into an easy-to-use adjunct for the detection of parathyroid glands accidentally resected intraoperatively.将基于探针的荧光系统转化为一种易于使用的辅助手段，用于检测术中意外切除的甲状旁腺。
Langenbecks Arch Surg. 2023 Jul 1;408(1):262. doi: 10.1007/s00423-023-02985-3.
4
Preliminary experience with the EleVision IR system in detection of parathyroid glands autofluorescence and perfusion assessment with ICG.EleVision IR 系统在检测甲状旁腺自发荧光和 ICG 灌注评估中的初步经验。
Front Endocrinol (Lausanne). 2022 Oct 17;13:1030007. doi: 10.3389/fendo.2022.1030007. eCollection 2022.
5
Label-Free Enhancement of Adrenal Gland Visualization Using Near-Infrared Autofluorescence for Surgical Guidance.无标记增强近红外自发荧光在手术指导中的肾上腺可视化。
World J Surg. 2023 Feb;47(2):350-360. doi: 10.1007/s00268-022-06755-y. Epub 2022 Oct 2.
6
Adrenal Near-Infrared Autofluorescence.肾上腺近红外自体荧光
J Endocr Soc. 2022 Aug 15;6(10):bvac126. doi: 10.1210/jendso/bvac126. eCollection 2022 Oct 1.
7
[Research progress of autofluorescence imaging of parathyroid glands].[甲状旁腺自体荧光成像的研究进展]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 May;36(5):397-401. doi: 10.13201/j.issn.2096-7993.2022.05.016.
8
Indocyanine Green Angiography for Parathyroid Gland Evaluation during Transoral Endoscopic Thyroidectomy.经口内镜甲状腺切除术中吲哚菁绿血管造影术用于甲状旁腺评估
J Pers Med. 2021 Aug 27;11(9):843. doi: 10.3390/jpm11090843.
9
Current state of intraoperative use of near infrared fluorescence for parathyroid identification and preservation.甲状旁腺术中近红外荧光识别与保护的应用现状。
Surgery. 2021 Apr;169(4):868-878. doi: 10.1016/j.surg.2020.09.014. Epub 2020 Nov 1.
10
Detecting the Near Infrared Autofluorescence of the Human Parathyroid: Hype or Opportunity?检测人甲状旁腺的近红外自体荧光：炒作还是机遇？
Ann Surg. 2020 Dec;272(6):973-985. doi: 10.1097/SLA.0000000000003700.
本文引用的文献
1
Detection of Parathyroid Autofluorescence Using Near-Infrared Imaging: A Multicenter Analysis of Concordance Between Different Surgeons.使用近红外成像检测甲状旁腺自发荧光：不同外科医生之间一致性的多中心分析。
Ann Surg Oncol. 2018 Apr;25(4):957-962. doi: 10.1245/s10434-018-6364-2. Epub 2018 Feb 6.
2
Intraoperative real-time localization of parathyroid gland with near infrared fluorescence imaging.近红外荧光成像技术在甲状旁腺术中实时定位的应用
Gland Surg. 2017 Oct;6(5):516-524. doi: 10.21037/gs.2017.05.08.
3
Impact of autofluorescence-based identification of parathyroids during total thyroidectomy on postoperative hypocalcemia: a before and after controlled study.全甲状腺切除术中基于自体荧光识别甲状旁腺对术后低钙血症的影响：一项前后对照研究。
Surgery. 2018 Jan;163(1):23-30. doi: 10.1016/j.surg.2017.06.022. Epub 2017 Nov 6.
4
Increased identification of parathyroid glands using near infrared light during thyroid and parathyroid surgery.在甲状腺和甲状旁腺手术中使用近红外光增加甲状旁腺的识别。
Surg Endosc. 2017 Sep;31(9):3737-3742. doi: 10.1007/s00464-017-5424-1. Epub 2017 Mar 31.
5
Intraoperative near-infrared autofluorescence imaging of parathyroid glands.甲状旁腺的术中近红外自发荧光成像
Surg Endosc. 2017 Aug;31(8):3140-3145. doi: 10.1007/s00464-016-5338-3. Epub 2016 Nov 14.
6
Intraoperative Real-Time Localization of Normal Parathyroid Glands With Autofluorescence Imaging.术中利用自体荧光成像对正常甲状旁腺进行实时定位
J Clin Endocrinol Metab. 2016 Dec;101(12):4646-4652. doi: 10.1210/jc.2016-2558. Epub 2016 Sep 20.
7
Intraoperative Near-infrared Imaging for Parathyroid Gland Identification by Auto-fluorescence: A Feasibility Study.术中近红外成像通过自体荧光识别甲状旁腺：一项可行性研究。
World J Surg. 2016 Sep;40(9):2131-8. doi: 10.1007/s00268-016-3571-5.
8
Cutting Edge in Thyroid Surgery: Autofluorescence of Parathyroid Glands.甲状腺手术前沿：甲状旁腺的自体荧光
J Am Coll Surg. 2016 Aug;223(2):374-80. doi: 10.1016/j.jamcollsurg.2016.04.049. Epub 2016 May 20.
9
Establishing the clinical utility of autofluorescence spectroscopy for parathyroid detection.确立自体荧光光谱法在甲状旁腺检测中的临床应用价值。
Surgery. 2016 Jan;159(1):193-202. doi: 10.1016/j.surg.2015.06.047. Epub 2015 Oct 9.
10
Near-infrared autofluorescence for the detection of parathyroid glands.近红外自体荧光用于甲状旁腺的检测。
J Biomed Opt. 2011 Jun;16(6):067012. doi: 10.1117/1.3583571.
Zotero 插件