Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Doherty Applied Microbial Genomics, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Microb Genom. 2019 Jul;5(7). doi: 10.1099/mgen.0.000283. Epub 2019 Jul 22.
Vancomycin-resistant Enterococcus faecium (VREfm) is a globally significant public health threat and was listed on the World Health Organization's 2017 list of high-priority pathogens for which new treatments are urgently needed. Treatment options for invasive VREfm infections are very limited, and outcomes are often poor. Whole-genome sequencing is providing important new insights into VREfm evolution, drug resistance and hospital adaptation, and is increasingly being used to track VREfm transmission within hospitals to detect outbreaks and inform infection control practices. This mini-review provides an overview of recent data on the use of genomics to understand and respond to the global problem of VREfm.
万古霉素耐药粪肠球菌（VREfm）是一种具有全球重要意义的公共卫生威胁，被世界卫生组织（WHO）列入 2017 年需要紧急开发新疗法的高优先级病原体清单。侵袭性 VREfm 感染的治疗选择非常有限，且结果通常不佳。全基因组测序为了解 VREfm 的进化、耐药性和医院适应性提供了重要的新见解，并越来越多地用于跟踪医院内 VREfm 的传播，以发现暴发并为感染控制措施提供信息。这篇迷你综述概述了利用基因组学来了解和应对 VREfm 这一全球问题的最新数据。
