均相铕掺杂的钨酸钠和钼酸钠（NaLa（XO），X = Mo，W）探针的合成、功能化及发光和 X 射线计算机断层成像生物成像性能研究。

Synthesis, functionalization and properties of uniform europium-doped sodium lanthanum tungstate and molybdate (NaLa(XO), X = Mo,W) probes for luminescent and X-ray computed tomography bioimaging.

机构信息

Instituto de Ciencia de Materiales de Sevilla, CSIC-US, Américo Vespucio 49, 41092 Isla de la Cartuja, Sevilla, Spain.

Instituto de Ciencia de Materiales de Aragón, CSIC/UniZar and CIBER-BBN, Edificio I+D, Mariano Esquillor s/n, 50018 Zaragoza, Spain.

出版信息

J Colloid Interface Sci. 2019 Oct 15;554:520-530. doi: 10.1016/j.jcis.2019.07.031. Epub 2019 Jul 13.

DOI:10.1016/j.jcis.2019.07.031

PMID:31330425

Abstract

A one-pot simple procedure for the synthesis of uniform, ellipsoidal Eu-doped sodium lanthanum tungstate and molybdate (NaLa(XO), X  = W, Mo) nanophosphors, functionalized with carboxylate groups, is described. The method is based on a homogeneous precipitation process at 120 °C from appropriate Na, Ln and tungstate or molybdate precursors dissolved in ethylene glycol/water mixtures containing polyacrylic acid. A comparative study of the luminescent properties of both luminescent materials as a function of the Eu doping level has been performed to find the optimum nanophosphor, whose efficiency as X-ray computed tomography contrast agent is also evaluated and compared with that of a commercial probe. Finally, the cell viability and colloidal stability in physiological pH medium of the optimum samples have also been studied to assess their suitability for biomedical applications.

摘要

一种一锅简单法合成均匀的、椭圆形的 Eu 掺杂的钠镧钨酸盐和钼酸盐（NaLa（XO），X = W，Mo）纳米荧光粉，并用羧酸盐功能化，该方法基于在 120°C 下进行的均匀沉淀过程，使用溶解在含有聚丙烯酸的乙二醇/水混合物中的适当的 Na、Ln 和钨酸盐或钼酸盐前体制备。对两种发光材料的发光性能进行了Eu 掺杂水平的比较研究，以找到最佳的纳米荧光粉，并评估其作为 X 射线计算机断层扫描造影剂的效率，并与商业探针进行比较。最后，还研究了最佳样品在生理 pH 介质中的细胞活力和胶体稳定性，以评估它们在生物医学应用中的适用性。