Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Clin Gastroenterol Hepatol. 2020 May;18(5):1235-1237.e1. doi: 10.1016/j.cgh.2019.07.026. Epub 2019 Jul 20.
Conventional teaching is that Helicobacter pylori infection is required for the development of non-cardia gastric adenocarcinoma (NCGC) through a sequence of atrophic gastritis, intestinal metaplasia, dysplasia, and finally, cancer. However, studies have not demonstrated a 100% rate of H pylori infection in gastric malignancy, hypothesized to be due to false negatives, gastric atrophy leading to apparent loss of infection, and inclusion of cardia, nonintestinal cancers..
传统观点认为,幽门螺杆菌(Helicobacter pylori,H.pylori)感染是导致非贲门胃腺癌(non-cardia gastric adenocarcinoma,NCGC)发生的必要条件,其发展过程依次为萎缩性胃炎、肠化生、异型增生,最终进展为癌症。然而,研究并未在所有胃恶性肿瘤中均发现 100%的 H.pylori 感染率,这被认为是由于假阴性、胃萎缩导致的明显感染丢失以及贲门、非肠型癌症的包含等因素所致。