Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Med Phys. 2019 Oct;46(10):4685-4689. doi: 10.1002/mp.13732. Epub 2019 Aug 10.
The aim of this work is to describe a method of machine quality assurance (QA) by measuring proton spread-out Bragg peak constructed by the integrated depth dose via a large-diameter (12-cm) multilayer ionization chamber (LD-MLIC).
Two types of contours are used to create the nominal plan. The final nominal plan is composed of mixed-energy proton pencil-beam spots located close to the central axis. The integrated depth dose (IDD) curve contains a flat SOBP region. The LD-MLIC-measured IDD was compared to the IDD curve exported from the treatment planning system (TPS). In addition, three plans with intentionally modified energy layers to simulate wrong-delivered energy layers were created and measured by the LD-MLIC. The water equivalent thickness (WET) difference between the inserted and replaced energies was 0.2 cm. Six weeks of measurements were analyzed. A low-pass filter was introduced to mitigate the high-frequency noise in the IDD signal ratios. The filtered IDD signal ratios between the modified plans in different weeks and the baseline were used to check the energy accuracy.
The differences between the LD-MLIC-measured and TPS-exported IDDs of the nominal plan were within 2% in most parts of the curve. Bumps/dips (~1%) were noted in the filtered IDD ratio between the modified plans and the baseline.
The LD-MLIC can be used to check the accuracy of multiple energies Bragg peak locations quickly in proton machine QA. The LD-MLIC was sensitive in identifying an erroneous energy with 0.2 cm in WET.
本工作旨在描述一种通过使用大直径(12 厘米)多层电离室(LD-MLIC)测量集成深度剂量构建的质子扩展布拉格峰来进行机器质量保证(QA)的方法。
使用两种类型的轮廓来创建名义计划。最终的名义计划由靠近中央轴的混合能量质子铅笔束点组成。集成深度剂量(IDD)曲线包含一个平坦的 SOBP 区域。LD-MLIC 测量的 IDD 与从治疗计划系统(TPS)导出的 IDD 曲线进行了比较。此外,还创建了三个计划,故意修改了能量层,以模拟错误输送的能量层,并通过 LD-MLIC 进行了测量。插入和替换能量之间的水等效厚度(WET)差异为 0.2 厘米。对六周的测量结果进行了分析。引入低通滤波器以减轻 IDD 信号比中的高频噪声。在不同周的修改计划与基线之间的过滤后的 IDD 信号比用于检查能量准确性。
在名义计划的 LD-MLIC 测量和 TPS 导出的 IDD 之间,大多数曲线部分的差异在 2%以内。在修改计划与基线之间的过滤后的 IDD 比值中,注意到了凸起/凹陷(约 1%)。
LD-MLIC 可用于快速检查质子机 QA 中多个能量布拉格峰位置的准确性。LD-MLIC 能够灵敏地识别出具有 0.2 厘米 WET 的错误能量。