磁性纳米棒通过非加热低频磁场远程破坏脂质膜。
Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field.
机构信息
Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, Russia.
Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, Russia; National University of Science and Technology "MISIS" (MISIS), Moscow, Russia.
出版信息
Nanomedicine. 2019 Oct;21:102065. doi: 10.1016/j.nano.2019.102065. Epub 2019 Jul 23.
This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were demonstrated by the Attenuated total reflection Fourier Transform Infrared and fluorescence spectroscopy. Specifically, about 50% of hydrophobic chains became highly mobile under the action of ELF MF. Magnetic field-induced increase in the membrane fluidity was accompanied by an increase in membrane permeability and release of solutes entrapped in liposomes. The effect of ELF MF on the membrane fluidity was greater in case of 70 × 12 nm magnetite nanorods adsorbed on the liposomes surface compared to liposomes with ~7 nm spherical MNPs embedded within lipid membranes. A physical model of this process explaining experimental data is suggested. The obtained results open new horizons for the development of systems for triggered drug release without dangerous heating and overheating of tissues.
这项工作提供了脂质体膜在暴露于非加热交变极低频磁场（ELF MF）时被磁性纳米颗粒无序化的直接证据。通过衰减全反射傅里叶变换红外和荧光光谱证明了脂质膜结构的变化。具体来说，大约 50%的疏水链在 ELF MF 的作用下变得高度移动。磁场诱导的膜流动性增加伴随着膜通透性的增加和包封在脂质体中的溶质的释放。与嵌入脂质膜内的约 7nm 球形 MNPs 相比，吸附在脂质体表面的 70×12nm 磁铁矿纳米棒对膜流动性的影响更大。提出了一个解释实验数据的物理模型。这些结果为开发无需危险加热和组织过热的触发药物释放系统开辟了新的前景。
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