铱（III）配合物靶向癌细胞中的细胞凋亡
Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells.
机构信息
Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR 999077, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, Macau SAR 999078, China.
出版信息
Molecules. 2019 Jul 28;24(15):2739. doi: 10.3390/molecules24152739.
Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.
靶向细胞凋亡是设计抗癌药物的主要策略。近年来，非铂类支架已被开发为具有潜在更低毒性的抗癌药物的候选物，优于广泛使用的顺铂类似物。本综述重点介绍了开发作为抗癌剂的铱（III）配合物的最新进展，这些配合物特别通过靶向癌细胞中的细胞凋亡来发挥作用。
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