神经老年患者的药物依从性：一项观察性横断面研究。
Adherence to medication in neurogeriatric patients: an observational cross-sectional study.
机构信息
Department of Neurology, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
Center for Healthy Ageing, Jena University Hospital, Jena, Germany.
出版信息
BMC Public Health. 2019 Jul 29;19(1):1012. doi: 10.1186/s12889-019-7353-5.
BACKGROUND
Poor adherence is a major issue and is associated with increased morbidity, mortality, and immense costs for the healthcare system. Due to demographic changes, the burden of neurological diseases is increasing with a crucial exacerbation of the problem of nonadherence. However, comprehensive data on geriatric patients with neurological disorders do not exist to date. In this cross-sectional observational study we aim to identify disease-specific adherence-modulating factors in neurogeriatric patients.
METHODS
Patients 60 years or older with neurological disorders will receive an assessment of adherence (Stendal Adherence with Medication Score) and a comprehensive geriatric assessment during their stay in the Department of Neurology or Geriatrics at the Jena University Hospital (baseline data). In addition disease specific data will be derived from medical records. After one and twelve months a telephone interview will be conducted to evaluate if and why changes of medication occurred (follow up data).
DISCUSSION
This study aims to explore disease-specific patterns of nonadherence in elderly patients with neurological disorders and characteristics of information transfer between a specialized center, practicing neurologists, general practitioners, and the patients and their caregivers. This comprehensive data may help to develop and apply complex and disease-specific interventions to enhance adherence.
TRIAL REGISTRATION
German Clinical Trials Register DRKS00016774. Registered 19.02.2019.
背景
依从性差是一个主要问题，会增加发病率、死亡率，并给医疗系统带来巨大的成本。由于人口结构的变化，神经疾病的负担正在增加，不依从的问题也在急剧恶化。然而，迄今为止，还没有针对老年神经疾病患者的综合数据。在这项横断面观察性研究中，我们旨在确定神经老年患者中特定于疾病的依从性调节因素。
方法
年龄在 60 岁或以上、患有神经疾病的患者将在耶拿大学医院神经科或老年科住院期间接受依从性评估（Stendal 药物依从性评分）和全面的老年评估（基线数据）。此外，还将从病历中获取特定于疾病的数据。在一个月和十二个月时，将进行电话访谈，以评估是否以及为什么发生药物变化（随访数据）。
讨论
这项研究旨在探索老年神经疾病患者中特定于疾病的不依从模式，以及专门中心、执业神经科医生、全科医生与患者及其照顾者之间信息传递的特点。这些综合数据可能有助于制定和应用复杂的、特定于疾病的干预措施，以提高依从性。
试验注册
德国临床试验注册中心 DRKS00016774。注册于 2019 年 2 月 19 日。
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