Departments of Cardiology.
Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
J Cardiovasc Pharmacol. 2019 Nov;74(5):372-378. doi: 10.1097/FJC.0000000000000720.
Matrix mineralization can be divided into physiological mineralization and pathological mineralization. There is a consensus among existing studies that matrix vesicles (MVs) are the starting sites of bone mineralization, and each component of MVs serves a certain function in mineralization. In addition, ectopic MVs pathologically promote undesired calcification, the primary focus of which is the promotion of vascular calcification. However, the specific mechanisms of the actions of MVs in bone-vascular axis cross-talk have not been fully elucidated. This review summarizes the latest research in this field and explores the roles of MVs in the bone-vascular axis with the aim of generating new ideas for the prevention and treatment of vascular calcification and bone metabolic disease.
基质矿化可分为生理性矿化和病理性矿化。现有研究普遍认为基质小泡（MVs）是骨矿化的起始部位，MVs 的每个成分在矿化过程中都发挥着一定的作用。此外，异位 MVs 病理性地促进了不需要的钙化，其主要焦点是促进血管钙化。然而，MVs 在骨-血管轴相互作用中的作用的具体机制尚未完全阐明。本综述总结了该领域的最新研究成果，探讨了 MVs 在骨-血管轴中的作用，以期为防治血管钙化和骨代谢疾病提供新的思路。
