National University of Singapore, 21 Lower Kent Ridge Rd, Singapore, Singapore.
Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana, USA.
AAPS PharmSciTech. 2019 Jul 30;20(7):271. doi: 10.1208/s12249-019-1482-0.
Dry powder inhalers have attracted more interest over the years in every aspect related to them. Interestingly, when focusing on the effects of particle morphology of the active or carrier (excipient), it is generally regarded particle size and shape to influence drug availability of aerosolized particles. However, to date, few studies have examined the effect of texture, i.e., roughness, on this relationship. The main objective of the present work is to gain a closer understanding of the influence of carrier morphology on the aerosolization performance of dry powder inhaler formulations. Image analysis and microscopy were used to visualize the aerosolization process. It is considered that the scale of morphological features on the surface of the carrier particles is responsible for the dispersion of the powder formulation, separation of the drug/carrier, and entrainment from a dry powder inhaler. Thus, for this study, the carrier particles of different surface roughness were mixed with micronized salbutamol sulphate. Aerosolization in vitro testing was used to evaluate the performance. The results indicate a connection between the qualitative surface roughness of coarse carriers and aerosolization performance during powder dispersibility. This investigation demonstrated that indeed, powder dispersion, a dynamic process, is influenced by the scale of the carrier morphology.
干粉吸入器在各个方面都引起了更多的关注。有趣的是，当关注活性或载体（赋形剂）的颗粒形态的影响时，通常认为颗粒大小和形状会影响气溶胶化颗粒的药物可用性。然而，迄今为止，很少有研究考察纹理（即粗糙度）对这种关系的影响。本工作的主要目的是更深入地了解载体形态对干粉吸入器制剂气溶胶化性能的影响。图像分析和显微镜用于可视化气溶胶化过程。认为载体颗粒表面的形态特征的尺度负责粉末制剂的分散、药物/载体的分离以及从干粉吸入器夹带。因此，在这项研究中，不同表面粗糙度的载体颗粒与微米化硫酸沙丁胺醇混合。体外气溶胶化测试用于评估性能。结果表明，粗载体的定性表面粗糙度与粉末分散性期间的气溶胶化性能之间存在联系。这项研究表明，确实，粉末分散是一个动态过程，受到载体形态尺度的影响。
