Mutlu Melek, Sarac Ozge, Cağıl Nurullah, Avcıoğlu Gamze
World Eye Hospital Etiler, Vadi İstanbul Teras evleri 8.blok no:24, Istanbul, Turkey.
Department of Ophthalmology, Ataturk Education and Research Hospital, Yıldırım Beyazıt University, Ankara, Turkey.
Int Ophthalmol. 2020 Jan;40(1):51-57. doi: 10.1007/s10792-019-01149-x. Epub 2019 Jul 30.
To analyze the relationship between the seasonal allergic conjunctivitis (SAC), eotaxin-2, matrix metalloproteinase-9 (MMP-9), and the topographical findings in the keratoconus patients.
Thirty-four eyes of patients without SAC (Group 1), 34 eyes of patients with SAC (Group 2), and 20 eyes of control subjects (control group) were enrolled. Tear samples of the subjects were collected by Schirmer method. Corneal topography parameters, tear MMP-9, and tear eotaxin-2 levels were analyzed.
The mean tear MMP-9 levels in Groups 1 and 2 were significantly higher than in the control group (p = 0.004). MMP-9 level exhibited a positive correlation with the keratoconus stage and a negative correlation with the thinnest corneal thickness (r = 0.294, p = 0.018, and r = - 0.302, p = 0.006, respectively). The tear eotaxin-2 level was higher in Group 2 than in Group 1 and control group which is not statistically significant (p = 0.17).
The tear eotaxin-2 did not exhibit any difference in the presence of keratoconus. The tear MMP-9 level was higher in the keratoconic eyes, and it showed a correlation with the stage of the disease and the corneal thickness.
分析季节性变应性结膜炎（SAC）、嗜酸性粒细胞趋化因子-2、基质金属蛋白酶-9（MMP-9）与圆锥角膜患者的地形学检查结果之间的关系。
纳入34只无SAC患者的眼（第1组）、34只SAC患者的眼（第2组）和20只对照者的眼（对照组）。采用泪液滤纸条法收集受试者的泪液样本。分析角膜地形图参数、泪液MMP-9和泪液嗜酸性粒细胞趋化因子-2水平。
第1组和第2组的泪液MMP-9平均水平显著高于对照组（p = 0.004）。MMP-9水平与圆锥角膜分期呈正相关，与最薄角膜厚度呈负相关（r分别为0.294，p = 0.018；r为-0.302，p = 0.006）。第2组的泪液嗜酸性粒细胞趋化因子-2水平高于第1组和对照组，但差异无统计学意义（p = 0.17）。
泪液嗜酸性粒细胞趋化因子-2在圆锥角膜患者中无差异。圆锥角膜患眼的泪液MMP-9水平较高，且与疾病分期和角膜厚度相关。
